Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity


Attention Deficit Disorder With Hyperactivity is associated with deficits in cognition and sleep. In healthy adults, memory consolidation processes are related to sleep spindle activity in the sleep electroencephalogram. This association is poorly characterized in adults with attention deficit hyperactivity. In this study, the purpose is to characterize sleep microarchitecture disorders through the analysis of different stage of sleep EEG activity during a polysomnographic examination in adult with mixed Attention Deficit Disorder With Hyperactivity presentation compared to healthy.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Other
    • Masking: None (Open Label)
  • Study Primary Completion Date: May 31, 2025


  • Other: Neurological examinations
    • Neurological, neuropsychological, polysomnography examinations and multiple sleep latency test. The protocol is divided into three visits.

Arms, Groups and Cohorts

  • Experimental: Attention Deficit Disorder With Hyperactivity
    • Patients with Attention Deficit Disorder With Hyperactivity. Same examinations than control group
  • Active Comparator: Control
    • Healthy volunteers Same examinations than Attention Deficit Disorder With Hyperactivity group

Clinical Trial Outcome Measures

Primary Measures

  • Difference in signal power (db or μV 2) in the sigma frequency bands in N2 sleep
    • Time Frame: 1 day
    • difference between 2 groups

Participating in This Clinical Trial

Inclusion Criteria for all participants:

  • Age from 18 to 45 years old – Affiliated to the French health care system Inclusion Criteria for attention deficit hyperactivity disorder patients: – meeting Diagnostic and Statistical Manual (DSM)-5 criteria for mixed attention deficit hyperactivity disorder presentation without drug treatment for attention deficit hyperactivity disorder. Exclusion Criteria for all participant: – People not able to give consent, neurological disease (other than neurodevelopmental disorders; or any other serious disease (cancer, addiction, systemic disease)), untreated sleep apnea, major depression (Beck inventory > 15), untreated restless leg syndrome; pregnancy in progress or wish to become pregnant during the study or breastfeeding woman, drug treatment including benzodiazepine, neuroleptic or antidepressant before inclusion. Exclusion Criteria for healthy volunteers: – Subjective cognitive and/or sleep complaint.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University Hospital, Toulouse
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Mélanie PLANTON, PhD, Principal Investigator, University Hospital, Toulouse
  • Overall Contact(s)
    • Mélanie PLANTON, PhD, 05 61 14 59 62,

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