The Predictive Value of Progesterone

Overview

To evaluate a 5 ng/ml serum progesterone (P4) threshold policy for the addition of subcutaneous (SC) P4 in artificially prepared frozen embryo transfer cycles treated with vaginal P4. We assess whether the addition of SC P4 rescues cycles with serum P4 <5 ng/ml and we study the impact of not supplementing cycles with serum P4 >5 ng/ml by comparing them with serum P4 cycles above the conventionally proposed cut-off of 10 ng/ml.

Full Title of Study: “The Predictive Value of the Progesterone Level on the Day of Embryo Transfer in Cryo Cycles”

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Retrospective
• Study Primary Completion Date: December 31, 2025

Clinical Trial Outcome Measures

Primary Measures

• Ongoing pregnancy rate
  • Time Frame: 11 to 13 weeks after ovulation
  • Fetal heart beat at ultrasound

Secondary Measures

• Clinical pregnancy rate
  • Time Frame: 6 to 8 weeks after ovulation
  • Positive hCG and ultrasound visualisation of the gestational sac

Participating in This Clinical Trial

Embryo transfer between March 1st 2021 and March 31st 2023 – Determination of progesterone on the day of embryo transfer

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 47 Years

Are Healthy Volunteers Accepted: No

Investigator Details

• Lead Sponsor
  • University Hospital, Ghent
• Provider of Information About this Clinical Study
  • Sponsor
• Overall Official(s)
  • Dominic Stoop, MD, Principal Investigator, University Hospital, Ghent
• Overall Contact(s)
  • Sara Somers, MSc, 003293323048, studieco.vrouwenkliniek@uzgent.be