Low Level Laser Therapy Applied in Orthodontic Tooth Movement

Overview

Currently, orthodontic treatment takes 2-3 years.. If we accelerate tooth movement by low energy laser therapy, we could reduce treatment time. Low Level Laser Therapy(LLLT) applied in Orthodontic Tooth Movement, which stimulates formation of osteoclast-like cells expression in vitro. Osteoclast can be served as an index for tooth movement. Increasing the number of osteoclast will increase bone formation and tooth movement. We plan to find a useful clinical protocol to improve the efficiency of orthodontic tooth movement. Test low energy laser in vitro. Find an effective wavelength and irradiation time to stimulate formation of osteoclast. Develop an useful protocol that clinical orthodontist could follow and reduce orthodontic treatment time.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Device Feasibility
    • Masking: Triple (Participant, Care Provider, Outcomes Assessor)
  • Study Primary Completion Date: August 26, 2022

Interventions

  • Device: Low Level Laser Therapy
    • Low level laser therapy could provide energy to trigger cell differentiation.
  • Other: Placebo
    • Placebo

Arms, Groups and Cohorts

  • Experimental: with LLLT
  • Placebo Comparator: without LLLT

Clinical Trial Outcome Measures

Primary Measures

  • Orthodontic tooth movement
    • Time Frame: 1-6month
    • the distance between canine and premolar

Secondary Measures

  • bone density after Orthodontic tooth movement
    • Time Frame: 1-6month
    • bone density change around canine

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with good oral hygiene, and over 18 years old, without serious medical history. Patients who required bilateral canine retraction into the extracted premolar sites were recruited. Exclusion Criteria:

  • (1) poor oral hygiene (2) previous orthodontic treatment (3) orthognathic surgery or syndromic patients

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • China Medical University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • SHENG-FEN HUANG, Study Chair, China Medical University Hospital
  • Overall Contact(s)
    • Jian-hong Yu, doctor, +886 422053366, kenkoyu@mail.cmu.edu.tw

Citations Reporting on Results

Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci. 2014 Spring;5(2):58-62.

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