Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors

Overview

The goal of this observational study is to compare the immune function and infection mechanism of patients with hematologic tumors and those people without underlying diseases after infection with SARS-CoV-2. Clinical characteristics, treatment options and responses will be collected. Peripheral blood will be collected from patients with hematologic tumors infected with SARS-CoV-2 and those people without underlying diseases infected with SARS-CoV-2.

Full Title of Study: “Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors and Discovery of Potential Drug Targets”

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Prospective
• Study Primary Completion Date: June 2023

Detailed Description

To establish a retrospective and prospective cohort of patients with hematologic tumors infected with SARS-CoV-2 and people without underlying diseases infected with SARS-CoV-2. Firstly, peripheral blood samples will be collected at infection time points and after SARS-CoV-2 nucleic acid testing turns negative. Subsequently, the transcriptome sequencing and immunological experiments will be performed to analyze the differentially expressed genes, immune function of cells, etc. Comparative analysis: 1. To compare the immune function of patients with hematologic tumors and those without underlying diseases after infection with SARS-CoV-2. 2. The transcriptomic and proteomic changes of patients with hematologic tumors are compared with those without underlying diseases after infection with SARS-CoV-2. 3. From the perspective of complex (human protein interaction subnetwork), the dynamic change process of SARS-CoV-2-targeted human protein complex (periodic complex) was deeply explored, in order to further analyze its potential dynamic infection mechanism and provide new clues for the discovery of drug targets.

Interventions

• Other: None intervention
  • None intervention.

Arms, Groups and Cohorts

• Patients with SARS-CoV-2 positive hematologic tumors
  • Patients with SARS-CoV-2 positive hematologic tumors over 18 years old excluding patients with severe diseases associated with other systems.
• People with SARS-CoV-2 positive without underlying diseases
  • People with SARS-CoV-2 positive without underlying diseases over 18 years old excluding people with severe diseases associated with other systems.

Clinical Trial Outcome Measures

Primary Measures

• Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors
  • Time Frame: 1 year
  • To compare the infection mechanism and immune function of patients with hematologic tumors infected with SARS-CoV-2 and people infected with SARS-CoV-2 without underlying diseases.

Participating in This Clinical Trial

Inclusion Criteria

• Clinical diagnosis of hematologic tumors Clinical diagnosis of SARS-CoV-2 infection Exclusion Criteria:

• Severe diseases associated with other systems

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

• Lead Sponsor
  • Peking University First Hospital
• Provider of Information About this Clinical Study
  • Principal Investigator: Yujun DONG, chief of department of hematology – Peking University First Hospital

References

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