Biomarker-s of Abusive Head Trauma by Proteomics

Overview

The aim of our study is to highlight biomarker-s of Abusive Head Trauma by proteomics analyses on the serum of child victims of abuse.

Full Title of Study: “Identification of Novel Biomarker-s of Abusive Head Trauma on Serum by Proteomics”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2027

Interventions

  • Other: Blood test
    • Proteomic analyses on serum

Arms, Groups and Cohorts

  • Abusive Head Trauma (AHT)
  • Accidental traumatic brain injury
  • Cranioplasty
  • Infant malaise without AHT

Clinical Trial Outcome Measures

Primary Measures

  • Highlight novel biomarker-s of AHT
    • Time Frame: Hospital admission to discharge (up to 3 days)
    • Proteomic analyses will be made on serum of infant victim of AHT. Results will be compare with control groups (traumatic brain injury, cranioplasty, malaise).

Participating in This Clinical Trial

Inclusion Criteria

  • Age : 0-2 y.o – Medical consultation for malaise, seizure (without fever), loss of consciousness, traumatic bain injury, or cranioplasty – Blood test during medical care – Accepted informed consent Exclusion Criteria:

  • Refused informed consent – For control groups : medical history of child abuse – For AHT group : rare metabolic disease (Menkes, etc..)

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 2 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University Hospital, Geneva
  • Collaborator
    • Hospices Civils de Lyon
  • Provider of Information About this Clinical Study
    • Principal Investigator: Kim Wiskott, Dre Kim Wiskott – University Hospital, Geneva
  • Overall Official(s)
    • Tony Fracasso, Prof., Study Director, University Hospital, Geneva
  • Overall Contact(s)
    • Kim Wiskott, MD, 0041797737424, kim.wiskott@hcuge.ch

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