The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste

Overview

In our study, we used nitrofurantoin as a root canal medication in patients suffering from symptomatic irreversible pulpitis in alleviating pain compared with double antibiotic paste.

Full Title of Study: “The Effectiveness of Single Antibiotic Paste Nitrofurantoin V/S Double Antibiotic Paste in Alleviation of Post-Operative Pain in Adult Patients Symptomatic Irreversible Pulpitis”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Single (Participant)
  • Study Primary Completion Date: October 24, 2022

Detailed Description

This study aims to compare the efficacy in alleviating pain between intracanal medicaments Nitrofurantoin versus double antibiotic paste.

Interventions

  • Drug: Nitrofurantoin
    • Nitrofurantoin has been found to successfully eradicate gram-negative bacteria such as Enterococcus faecalis that one of the most important bacteria in endodontic lesions
  • Drug: Double Antibiotic
    • DAP is a combination of two antibiotics which are ciprofloxacin and metronidazole

Arms, Groups and Cohorts

  • Experimental: Nitrofurantoin
  • Experimental: Double antibiotic paste
  • No Intervention: Control

Clinical Trial Outcome Measures

Primary Measures

  • To alleviate dental pain
    • Time Frame: 12 hours upto 72 hours following placement of intracanal medicament
    • Dental pain will be measured by using Visual Analogue Scale(VAS) which is an 10-point scale from 0-10 where 0 represents no pain and 10 represents the worst pain measured

Participating in This Clinical Trial

Inclusion Criteria

  • No medical history – no history of allergy to medications used in root canal treatment – patients suffering from Symptomatic Irreversible Pulpitis Exclusion Criteria:

  • Patients who were not suitable for conventional root canal treatment – multirooted teeth

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Altamash Institute of Dental Medicine
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hira Abbasi, Principal Investigator – Altamash Institute of Dental Medicine

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