Sarcopenia After Bariatric Surgery in Older Patients: A Cohort Study

Overview

The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: October 31, 2024

Detailed Description

The aim of the study is to compare the prevalence of sarcopenia and nutritional status between adults older than 65 years who have previously undergone bariatric surgery and patients with obesity but without previous bariatric surgery. Current sarcopenia will be assessed during a cross-sectional assessment after surgery using the criteria from the European Working Group on Sarcopenia in Older People (EWGSOP).

Interventions

  • Procedure: Bariatric surgery
    • Bariatric surgery

Arms, Groups and Cohorts

  • Cohort 1
    • Cohort 1: Older patients with overweight, obesity after bariatric surgery
  • Cohort 2
    • Cohort 2: Older patients with overweight, obesity without bariatric surgery

Clinical Trial Outcome Measures

Primary Measures

  • The number of older patients with sarcopenia after bariatric surgery compared to non-surgical control patients.
    • Time Frame: At least one year post surgery
    • a) Sarcopenia will be classified according to the criteria form the European Working Group on Sarcopenia in Older People revised guidelines (EWGSOP2) based on skeletal muscle mass, muscle strength and physical performance criteria.

Secondary Measures

  • 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients
    • Time Frame: At least one year post surgery
    • 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients
  • 2. The prevalence of nutrient deficiencies in older patients after bariatric surgery compared to non-surgical control patients.
    • Time Frame: At least one year post surgery
    • a. Indices of nutrient deficiencies will include reported dietary intake of protein, zinc, selenium, and blood levels of Vitamin D, zinc, and selenium.
  • 3. Markers of chronic systemic inflammation in older patients after bariatric surgery compared to non-surgical control patients
    • Time Frame: At least one year post surgery
    • Inflammatory markers will include CRP, IL-1β, IL-6, IL-8, TNF-α

Participating in This Clinical Trial

Inclusion Criteria

  • Signed informed consent – Age 65 years or older – Cohort 1 (exposed): Previous bariatric surgery for obesity at least 1 one year ago – Cohort 2 (unexposed): No previous weight loss surgery Exclusion Criteria:

  • Current diagnosis of cancer – Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4. – Immobility – Neuromuscular degenerative conditions

Gender Eligibility: All

Minimum Age: 65 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Universitaire Ziekenhuizen KU Leuven
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Bart Van der Schueren, MD, PhD, +3216346994, bart.vanderschueren@uzleuven.be

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