Combined Phacoemulsification and Diode Laser Therapy in Chronic Angle Closure Glaucoma
Overview
comparing different types of cuclophotocoagulation with cataract extraction to cataract extraction and goniocynechiolysis in cases of chronic angle closure glaucoma
Full Title of Study: “Combined Phacoemulsification and Different Modes of Diode Laser Therapy in Management of Chronic Angle Closure Glaucoma. A Comparative Study”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
- Study Primary Completion Date: October 1, 2023
Detailed Description
Evaluation of the safety of MP-TSCPC , CW-TSCPC and endoscopic cyclophotocoagulation when combined with phacoemulsification in cases with CACG Comparing the efficacy of the combined procedures in control of the IOP and the success rate versus lens extraction combined with synechiolysis
Interventions
- Procedure: phaco+MP-TSCPC
- The procedure starts with performing the cyclophotocoagulation using the Micropulse P3 device (IQ 810 Laser Systems; Iridex, Mountain View, CA, USA) at 2500 mW with a duration of 90 seconds in each hemisphere at a 31.3% duty cycle under local anesthesia and then performing phacoemulsification and IOL implantation.
- Procedure: phaco+TSCPC
- The procedure starts with performing the cyclophotocoagulation using the IRIDEX’s G probe device (IRIDEX Corp. Mountain View, CA, USA) at 1500 to2000 mW with a duration of 1500 ms applying about 15 shots in one hemisphere only under local anesthesia and then performing phacoemulsification and IOL implantation.
- Procedure: phaco+endocyclophotocoagulation
- phacoemulsification will be done and endocyclophotocoagulation will be done after cataract extraction
- Procedure: phaco GSL
- phacoemulsification will be done and then the angle is visualized by direct goniolens then the synechia are dissected by cohesive viscoelastic.
Arms, Groups and Cohorts
- Experimental: A:phaco+MP-TSCPC
- 22 patients with primary angle closure glaucoma will undergo phacoemulsification and micropulse cyclophotocoagulation
- Experimental: B:phaco+TSCPC
- 22 patients with primary angle closure glaucoma will undergo phaco and transscleral cyclophotocoagulation
- Experimental: C:phaco+endocyclophotocoagulation
- 22 patients with primary angle closure glaucoma will undergo phaco and endocyclophotocoagulation after cataract removal
- Experimental: D:phaco GSL
- 22 patients with primary angle closure glaucoma will undergo phaco and goniosynechiolysis
Clinical Trial Outcome Measures
Primary Measures
- the percentage of intraocular pressure change
- Time Frame: 6 Months
- measuring the intraocular pressure after 1M, 3M and 6M
Secondary Measures
- percent change of antiglaucoma medications
- Time Frame: 6 Months
- the number of medication before and after the procedure
Participating in This Clinical Trial
Inclusion Criteria
- Patients between 20 to 70 years chronic angle closure glaucoma Exclusion Criteria:
- Patients in acute attack of angle closure. – Patients with previous filtering surgery or cycloablative procedure
Gender Eligibility: All
Minimum Age: 20 Years
Maximum Age: 70 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Cairo University
- Provider of Information About this Clinical Study
- Principal Investigator: Fayrouz Aboalazayem, lecturer – Cairo University
- Overall Official(s)
- Ahmed Abdelrahman, PhD, Study Chair, kasr alainy
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