Assesment of Two Different Modalities of Maxillary Canine Retraction Assisted With Injectable Platelet Rich Fibrin

Overview

The present prospective clinical study will be undertaken for assessment of two different modalities of maxillary canine retraction assisted with injectable platelet rich fibrin.

Full Title of Study: “Assesment of Two Different Modalities of Maxillary Canine Retraction Assisted With Injectable Platelet Rich Fibrin: A Prospective Clinical Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Factorial Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: March 1, 2023

Interventions

  • Biological: Injectable platelet rich fibrin .
    • i-PRF with maxillary canine retraction that will be performed two times on intervention sides according to a standardized protocol.
  • Biological: Injectable platelet rich fibrin .
    • i-PRF that will be performed four times on intervention sides according to a standardized protocol.

Arms, Groups and Cohorts

  • Active Comparator: Group I
    • will include 9 patients
  • Active Comparator: Group II
    • will include 9 patients.

Clinical Trial Outcome Measures

Primary Measures

  • acceleration of canine retraction
    • Time Frame: post interventional at 4 months
    • rate of canine retraction

Participating in This Clinical Trial

Inclusion Criteria

  • An age range from 15-22 years. – Severe crowding or protrusion requiring 1st premolars extractions followed by symmetrical canine retraction. – All permanent teeth present, 3rd molars are excluded. – Good oral and general health. – No systemic disease/medication that could interfere with OTM. No previous orthodontic treatment. Exclusion Criteria:

  • Patient diagnosed to have an indication for non-extraction approach. – Poor oral hygiene or periodontally compromised patient. – Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions.

Gender Eligibility: All

Minimum Age: 15 Years

Maximum Age: 22 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Al-Azhar University
  • Provider of Information About this Clinical Study
    • Principal Investigator: mohamed radwan mohamed radwan el shamy, Principal investigator – Al-Azhar University
  • Overall Official(s)
    • mohamed radwan, student, Principal Investigator, Al-Azhar University

References

Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement : A randomized split-mouth-controlled trial. J Orofac Orthop. 2021 Jul;82(4):268-277. doi: 10.1007/s00056-020-00275-x. Epub 2021 Jan 22.

Erdur EA, Karakaslı K, Oncu E, Ozturk B, Hakkı S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021 May 1;91(3):285-292. doi: 10.2319/060320-508.1.

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