Correlation Between Environmental Pollution and Gestational Diabetes Mellitus

Overview

Gestational diabetes mellitus (GDM) refers to the abnormal glucose metabolism index of pregnant women during pregnancy. At present, about 15% of pregnant women will develop GDM in the second and third trimester, which seriously affects the health of the pregnant woman and the fetus. However, the etiology of GDM remains unclear. Various pollutants in the environment may have a potential impact on pregnant women and fetuses. For example, previous studies have shown that exposure to atmospheric pollutants nitric oxide and organochlorine pesticides are associated with GDM. At present, we plan to further investigate the correlation between environmental pollutants and GDM.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 31, 2023

Interventions

  • Other: Clinical data and specimen collection
    • Questionnaire survey and clinical data was conducted when pregnant women were enrolled in the first trimester, and blood and urine were collected.

Arms, Groups and Cohorts

  • GDM group
    • Pregnant women with positive OGTT results at 24-28 gestational weeks
  • Control group
    • Pregnant women with negative OGTT results at 24-28 gestational weeks, and had baseline data that matched those in the GDM group

Clinical Trial Outcome Measures

Primary Measures

  • Environmental contaminants
    • Time Frame: First trimester (9-14 gestational weeks)
    • Environmental pollutants in serum and urine were analyzed by gas chromatography-mass spectrometry (GC-MS/MS), such as organochlorine pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers, metal elements, etc. Specimens were collected during the first trimester and tested when classified in the GDM or control group

Participating in This Clinical Trial

Inclusion Criteria

  • Plan to complete OGTT and give birth in the research center – First trimester – Singleton pregnancy – Without diabetes before pregnancy Exclusion Criteria:

  • Have diseases that affect metabolic function or even threaten the life of the mother and fetus before pregnancy, such as diabetes, hypertension, heart disease, liver and kidney diseases, thyroid diseases with drug, autoimmune diseases, malignant tumors, AIDS, etc. – Fetus has a known deformity or genetic defects – Incomplete clinical data – Assisted reproductive

Gender Eligibility: Female

Minimum Age: 20 Years

Maximum Age: 49 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Women’s Hospital School Of Medicine Zhejiang University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Zhaoxia Liang, Prof., 86571-89992115, xiaozaizai@zju.edu.cn

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