Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

Overview

There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: August 1, 2022

Detailed Description

In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.

Interventions

  • Diagnostic Test: prognostic nutritional index calculated from laboratory parameters
    • Calculated nutritional index using laboratory results of serum albumin, lymphocyte count, and cholesterol

Arms, Groups and Cohorts

  • brain tumor surgery
    • adult patients undergoing brain tumor surgery

Clinical Trial Outcome Measures

Primary Measures

  • predictability of prognostic nutritional index for mortality after brain tumor surgery
    • Time Frame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years
    • Odds ratio of prognostic nutritional index for postoperative mortality

Secondary Measures

  • predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery
    • Time Frame: From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years
    • Odds ratio of prognostic nutritional index for postoperative acute kidney injury
  • predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery
    • Time Frame: From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years
    • Odds ratio of prognostic nutritional index for postoperative renal replacement therapy
  • relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery
    • Time Frame: From date of surgery until the date of hospital discharge
    • Odds ratio of prognostic nutritional index for length of hospital stay

Participating in This Clinical Trial

Inclusion Criteria

  • adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea Exclusion Criteria:

  • Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol – Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Seoul National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Youn Joung Cho, MD, PhD, Clinical Associate Professor – Seoul National University Hospital
  • Overall Official(s)
    • Youn Joung Cho, MD, PhD, Principal Investigator, Seoul National University Hospital
  • Overall Contact(s)
    • Youn Joung Cho, MD, PhD, +82220722467, mingming7@gmail.com

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