LARS for Chinese Patients

Overview

Low anterior resection syndrome (LARS) frequently occurs in patients undergoing low anterior resection (LAR). However, the incidence, exact mechanism and risk factors of major LARS largely variate in different studies. Considering varieties and differences of patient characteristics between Chinese patients and the western ones, this retrospective study aims to investigate the incidence of LARS in Chinese patients undergoing laparoscopic LAR, and to explore perioperative risk factors that might be associated with major LARS. Consequent patients undergoing laparoscopic LAR and free from disease recurrence from January 2015 to May 2021 were issued with LARS questionnaire. Incidence of LARS and patient data were collected and analyzed.

Full Title of Study: “The Incidence and Risk Factors of Low Anterior Resection Syndrome: Basing on Data of Chinese Patients From a Single Center”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: May 2021

Interventions

  • Diagnostic Test: LARS questionnaire
    • Eligible participants were issued with LARS questionnaire (Chinese version) by E-mail, message, phone or face to face interview.

Clinical Trial Outcome Measures

Primary Measures

  • incidence of LARS
    • Time Frame: at least 1 months postoperatively
    • incidence of Low Anterior Resection Syndrome
  • incidence of major LARS
    • Time Frame: at least 1 months postoperatively
    • incidence of major Low Anterior Resection Syndrome

Participating in This Clinical Trial

Inclusion Criteria

Patients diagnosed as rectal cancer and underwent radical laparoscopic LAR and straight colorectal/coloanal anastomosis (with or without a protective stoma) by a same surgical team Exclusion Criteria:

either local or distal recurrence, severe complications such as postoperative anastomotic leakage, failure of protective stoma closure, data missed and no responding to LARS questionnaire

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Third Affiliated Hospital, Sun Yat-Sen University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hongbo Wei, Vice-president of Third Affiliated Hospital, Sun Yat-Sen University – Third Affiliated Hospital, Sun Yat-Sen University

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