Effect of a Third COVID-19 Booster Among Health Care Workers

Overview

A new wave of COVID-19 infections, mainly caused by the Omicron/ Delta variant, has been sweeping the globe since the start of 2022. In response, the administration of a third dose of COVID-19 vaccine was considered to address potential waning immunity over time and reduced effectiveness against the Omicron/ Delta variant. The pandemic also resulted in many infections among health care workers (HCWs) and their households. In this study, a retrospective analysis would perform on risk of COVID-19 infection and their outcome in relation to their COVID-19 vaccination history by using the data repository from one of the Hong Kong private hospitals. HCWs were required to submit a standardized online self-declaration form for report of 1) demographic of the HCWs, 2) symptoms related history and 3) COVID-19 exposure history once they were COVID-19 confirmed by rapid antigen test against COVID-19 and/or polymerase chain reaction (PCR) test for COVID-19. Subsequent follow up such as contact tracing, COVID-19 PCR testing results of these HCWs and status of return to work were captured by the infection control team in a systematic manner.

Full Title of Study: “Effect of a Third COVID-19 Booster on COVID-19 Infection Rate and Return to Works During Fifth Wave COVID-19 Among Health Care Workers”

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Retrospective
• Study Primary Completion Date: July 31, 2022

Interventions

• Biological: Third COVID-19 booster
  • Third COVID-19 booster

Arms, Groups and Cohorts

• Health care workers without third COVID-19 booster
  • Health care workers received less than 3 doses of COVID-19 vaccine
• HCWs with third COVID-19 booster
  • Health care workers received at least 3 doses of COVID-19 vaccine

Clinical Trial Outcome Measures

Primary Measures

• COVID-19 Infection
  • Time Frame: During 1 February – 31 March 2022
  • Infection of COVID-19
• Number of days return to work after COVID-19 infection
  • Time Frame: During 1 February – 31 March 2022
  • Number of days return to work after COVID-19 infection

Participating in This Clinical Trial

Inclusion Criteria

• All full time staff members of the private hospital Exclusion Criteria:

• History of COVID-19 before 2022

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

• Lead Sponsor
  • Hong Kong Sanatorium & Hospital
• Provider of Information About this Clinical Study
  • Principal Investigator: Dr. Jonpaul ST Zee, Specialist in Infectious Disease – Hong Kong Sanatorium & Hospital
• Overall Official(s)
  • Jonpaul Sze Tsing Zee, MBChB, Principal Investigator, Hong Kong Sanatorium & Hospital
• Overall Contact(s)
  • Jonpaul Sze Tsing Zee, MBChB, 28357064, Jonpaul.ST.Zee@hksh.com