BFR in Overweight Sedentary Subjects

Overview

This project should allow the investigators to observe the effects of low load training under partial vascular occlusion (BFR) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. Training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a "classic" type training with heavy loads. Thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

Full Title of Study: “Effects of a Physical Activity Program With Partial Vascular Occlusion on Body Composition, Biomechanics and Walking Energy in Overweight Sedentary Subjects”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: Single (Participant)
  • Study Primary Completion Date: April 15, 2022

Detailed Description

The main objective of this study is to observe the effects of low load training under vascular occlusion (BFR) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients. 3.2 Primary and secondary endpoints The first hypothesis is that the BFR drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns. The second hypothesis is that BFR training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. In addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol. 3.3 Study design This single-center project aims to test the effects of low-load training under partial vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion in overweight sedentary people. The main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. This project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

Interventions

  • Other: Exercise Intervention
    • Training with light load with blood flow restriction (BFR)

Arms, Groups and Cohorts

  • Experimental: Blood Flow Restriction
    • Use of the BFR cuff during the training intervention
  • Active Comparator: control
    • No use of inflated cuff

Clinical Trial Outcome Measures

Primary Measures

  • DEXA technology
    • Time Frame: One week before intervention
    • Body composition assessment: relative lean and fat mass in all body segments
  • DEXA technology
    • Time Frame: One week following the training intervention
    • Body composition assessment: relative lean and fat mass in all body segments
  • Evaluation of muscle strength from an isokinetic device
    • Time Frame: One week before intervention
    • eccentric and concentric peak torque of the knee extensor muscles
  • Evaluation of muscle strength from an isokinetic device
    • Time Frame: One week following the training intervention
    • eccentric and concentric peak torque of the knee extensor muscles
  • Evaluation of the preferential speed of walking in an ecological situation
    • Time Frame: One week before interventionn
    • using of a treadmill with measurement of the ground reaction forces
  • Evaluation of the preferential speed of walking in an ecological situation
    • Time Frame: One week following the training intervention
    • using of a treadmill with measurement of the ground reaction forces
  • Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.
    • Time Frame: One week before intervention
    • calculation of the mechanical work
  • Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.
    • Time Frame: One week following the training intervention
    • calculation of the mechanical work
  • Evaluation of the energy cost of walking
    • Time Frame: One week before intervention
    • on a treadmill, by indirect calorimetry with gaz exchanges
  • Evaluation of the energy cost of walking
    • Time Frame: One week following the training intervention
    • on a treadmill, by indirect calorimetry with gaz exchanges

Participating in This Clinical Trial

Inclusion Criteria

  • IMC between 25 and 35 – vaccin against Covid-19 Exclusion Criteria:

hypertension diabete

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Lausanne
  • Provider of Information About this Clinical Study
    • Principal Investigator: Gregoire Millet, Professor – University of Lausanne

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