Breaking Sitting and Metabolic Health in Sedentary Lean Adults

Overview

The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary lean adults.

Full Title of Study: “Acute Effects of Breaking Prolonged Sitting on Postprandial Glycaemic Response, Incretin Hormones Secretion and Eating Behaviour in Sedentary Lean Adults”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: June 1, 2022

Detailed Description

Two trials are included – Prolonged sitting and Breaking sitting. In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.

Interventions

  • Behavioral: Prolonged sitting
    • After consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min.
  • Behavioral: Breaking sitting
    • After consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min.

Arms, Groups and Cohorts

  • Experimental: Prolonged sitting
    • Participants sat on a chair during the trial.
  • Experimental: Breaking sitting
    • Participants walked regularly during the trial.

Clinical Trial Outcome Measures

Primary Measures

  • Incremental area under curve (iAUC) for metabolic health
    • Time Frame: 320 minutes
    • Changes in incremental area under curve (iAUC) for insulin and glucose between trials

Secondary Measures

  • Gut hormones responses
    • Time Frame: 320 minutes
    • Changes in blood gut hormones responses (e.g., GLP-1, PYY and GIP, etc) between trials
  • Visual analogue scale (VAS)
    • Time Frame: 320 minutes
    • Changes in VAS from 0-100 mm (e.g., appetite and mood, etc.) between trials
  • Energy intake
    • Time Frame: 600 minutes after leaving the laboratory
    • Changes in energy intake (e.g, using a food diary to record) after leaving the laboratory until midnight
  • Physical activity level
    • Time Frame: 600 minutes after leaving the laboratory
    • Changes in physical activity level (e.g., using an accelerometer to record) after leaving the laboratory until midnight
  • Lipid profile
    • Time Frame: 320 minutes
    • Changes in blood lipid profile (e.g., TAG and cholesterol, etc.) between trials
  • Blood pressure
    • Time Frame: 320 minutes
    • Changes in blood pressure (systolic and diastolic blood pressure) between trials
  • Computerized cognitive testing
    • Time Frame: 320 minutes
    • Changes in cognitive function (e.g., accuracy and reaction time) between trials

Participating in This Clinical Trial

Inclusion Criteria

  • Physical inactive males and females – Aged between 20 and 45 years – Lean healthy (waist circumference less than 90 cm for males and 80 cm for females) – Weight stable for more than 3 months (no change in weight +/- 3%) – Non-smoker – Able to walk comfortably on a treadmill Exclusion Criteria:

  • Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia – Waist circumference > 90 cm for male and > 80 cm for female – Taking medications that may influence lipid or carbohydrate metabolism or immune system function – Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • National Taiwan Normal University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yung-Chih Chen, Principal Investigator – National Taiwan Normal University
  • Overall Official(s)
    • Yung-Chih Chen, PhD, Principal Investigator, Department of Physical Education and Sport Sciences, National Taiwan Normal University
  • Overall Contact(s)
    • Yung-Chih Chen, PhD, +886277496979, yc.chen@ntnu.edu.tw

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