Blood Loss Measurement Using Electrical Impedance Tomography


The project focuses on the possibility of detecting blood loss using electrical impedance tomography. Based on previous animal experiments, it was found that the bolus of saline significantly affects the signal of chest bioimpedance. It is assumed that blood loss of a similar volume will cause a similar signal change with the opposite trend. The aim of this project is to determine whether there is a significant change in the thoracic electrical impedance tomography signal when blood loss is caused by voluntary blood donation.

Full Title of Study: “Measurement of Blood Loss Using Electrical Impedance Tomography”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Supportive Care
    • Masking: None (Open Label)
  • Study Primary Completion Date: October 10, 2022

Detailed Description

Electrical impedance tomography is a bedside method of ventilation monitoring. The bioimpedance of the tissue depends, among other things, on its blood content. The area of the chest and especially the lungs is a heavily perfused tissue, which also serves as one of the reservoirs of blood in case of blood loss. It is therefore possible that blood loss will be visible on chest bioimpedance relatively soon. The study will be performed on voluntary blood donors. Blood loss of 450 mL will be caused by the collection of donated blood. During blood collection at the transfusion department, thoracic bioimpedance will be measured using electrical impedance tomography. The resulting signal change will then be analyzed to determine the possibility of detecting and measuring blood loss using electrical impedance tomography.


  • Device: Electrical impedance tomography measurement
    • During standard blood donation, donors’ chest bioimpedance will be measured using electrical impedance tomography.

Arms, Groups and Cohorts

  • Experimental: Voluntary blood donors
    • Voluntary blood donors undergoing standard blood donation while measuring electrical impedance of the chest .

Clinical Trial Outcome Measures

Primary Measures

  • Change in chest electrical impedance due to blood loss.
    • Time Frame: Time frame of one voluntary blood donation process (15 min)
    • A change in the electrical impedance of the chest of a voluntary blood donor caused by a blood donation.

Participating in This Clinical Trial

Inclusion Criteria

  • voluntary blood donation Exclusion Criteria:

  • standard exclusion criteria for voluntary blood donation based on the transfusion station protocol – standard exclusion criteria for electrical impedance tomography according to the manufacturer

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Czech Technical University in Prague
  • Collaborator
    • Military University Hospital, Prague
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Vaclav Ort, M.Eng., Principal Investigator, Czech Technical University in Prague, Fac. of Biomedical Engineering
  • Overall Contact(s)
    • Vaclav Ort, M.Eng., +420 731 577 649,

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