Caffeine Supplementation, Resistance Training and Blood Antioxidant Status

Overview

The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.

Full Title of Study: “Acute Effects of Caffeine Supplementation on Resistance Training Volume and Blood Antioxidant Status in Resitance Trained Men”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Treatment
    • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: September 2022

Detailed Description

Caffeine is one of the most commonly consumed psychoactive substances in the world. Several previous studies confirmed that caffeine improves several aspects of exercise performance, including resistance training outcomes. Interestingly, caffeine and its catabolic products, theobromine and xanthine, exhibit antioxidant and prooxidant properties. Additionally, resistance training promotes the generation of reactive oxygen species, which are important for the cellular adaptation process. Hovewer, to the best of our knowledge, there is no information as to how caffeine combined with resistance training affects blood antioxidant status. Therefore, the aim of this study was to examine acute effects of caffeine supplementation on resistance training volume and blood antioxidant status in resistance trained men.

Interventions

  • Dietary Supplement: Caffeine supplementation
    • Two identical experimental sessions with a one-week interval between sessions (to allow complete recovery and ensure substance wash-out) will be taken. During the experimental sessions, participants will ingest caffeine in dose of 3 mg/kg of body mass. Caffeine will be provided in capsules containing the individual amount of caffeine and will be administered orally 60 min before the onset of the exercise protocol.
  • Dietary Supplement: Placebo treatment
    • The experimental procedure for each particpant will include placebo supplementation. The manufacturer of the caffeine capsules will also prepare identical placebo capsules filled out with a microcrystalline cellulose. Placebo will be administered orally 60 min before the onset of the exercise protocol.

Arms, Groups and Cohorts

  • Experimental: Caffeine supplementation
    • Group taking 3 mg/kg of caffeine
  • Placebo Comparator: Placebo treatment
    • Group taking placebo

Clinical Trial Outcome Measures

Primary Measures

  • Change the levels of oxidative stress markers
    • Time Frame: Day 1, Day 2
    • Serum will be obtained for TOS/TOC (total oxidative stress), MDA (malondialdehyde), oncentration of TAS (total antioxidant status), activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx); concentartion of GSH (reduced glutathione) and UA (uric acid)
  • Changes in markers of muscle damage
    • Time Frame: Day 1, Day 2
    • Serum will be obtained for activity of creatine kinase (CK) and lactate dehydrogenase (LDH), concentration of myoglobin (Mb)
  • Changes in Inflammation markers
    • Time Frame: Day 1, Day 2
    • Serum will be obtained for level of interleukin 6, TNF alfa (tumor matrix factor), CRP (C-reactive protein)
  • Changes in markers of liver function
    • Time Frame: Day 1, Day 2
    • Serum will be obtained for activity of ASPAT (aspartate aminotransferase), ALAT (alanine aminotransferase) and gamma glutamyltransferase (GGT)

Secondary Measures

  • Changes in resistance training volume
    • Time Frame: During caffeine and placebo treatment
  • Changes in rate of perceived exertion after resistance training
    • Time Frame: Immediately after exercise protocol during caffeine and placebo treatment
  • Changes in heart rate during resistance training
    • Time Frame: During caffeine and placebo treatment
  • Changes in muscle soreness
    • Time Frame: prior to exercise, and 24, 48, 72, 96 and 120 hours post exercise.

Participating in This Clinical Trial

Inclusion Criteria

  • written consent to participate, – medical permission by physician – "resistance-trained," defined as having a minimum of two years of resistance training experience – minimum of 2 workout sessions per week in the last 6 months Exclusion Criteria:

  • neuromuscular or musculoskeletal disorders – current injury – using any medications, dietary supplements or ergogenic aids which could potentially affect the study outcomes – a positive smoking status – potential allergy to caffeine

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • The Jerzy Kukuczka Academy of Physical Education in Katowice
  • Provider of Information About this Clinical Study
    • Principal Investigator: Aleksandra Filip-Stachnik, PhD – The Jerzy Kukuczka Academy of Physical Education in Katowice
  • Overall Official(s)
    • Adam ZajÄ…c, Profesor, Study Director, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland
  • Overall Contact(s)
    • Aleksandra Filip-Stachnik, PhD, +48603931221, a.filip@awf.katowice.pl

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