Liver Status in Psychiatric Inpatients

Overview

Adults hospitalized in psychiatry have an increased frequency of somatic disorders, in particular various liver diseases (viral hepatitis, non-alcohol related liver steatosis, alcohol related liver disease). The evaluation of these liver disorders in psychiatric inpatients remains very little explored in France, contributing to the poor overall medical status of psychiatric patients. The LIVERSPIN study aims to estimate the prevalence rates of liver pathologies in psychiatric inpatients and to explore the factors associated with the existence of a liver pathology

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: December 15, 2023

Detailed Description

The LIVERSPIN study aims to estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease. All hospitalized patients can potentially be recruited. They will benefit from the usual clinical and paraclinical examinations as part of their hospitalization diagnostic work-up. For the determination of biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination.

Interventions

  • Diagnostic Test: To estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease.
    • Patients will receive the usual clinical and paraclinical examinations as part of their hospitalization diagnostic workup. For the biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination. Data will be collected from the patient, or if necessary from the health care team, using the medical record (interview and/or self-questionnaires).

Arms, Groups and Cohorts

  • Other: All inpatients in Vinatier psychiatric Hospital
    • All hospitalized patients can potentially be recruited. They will benefit from the usual clinical and paraclinical examinations as part of their hospitalization diagnostic work-up. For the determination of biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination.

Clinical Trial Outcome Measures

Primary Measures

  • HCV diagnosis
    • Time Frame: At inclusion
    • HCV diagnosis defined by positive HCV antibodies in blood

Secondary Measures

  • HBV diagnosis
    • Time Frame: At inclusion
    • HBV diagnosis defined by positive HBsAg in blood
  • HIV diagnosis
    • Time Frame: At inclusion
    • HIV diagnosis defined by positive anti-HIV1 or anti-HIV2 antibodies in blood
  • Suspicion of NAFLD
    • Time Frame: At inclusion
    • Suspicion of NAFLD on FIB-4 and the interrogation
  • Suspicion of alcoholic liver disease
    • Time Frame: At inclusion
    • Suspicion of alcoholic liver disease on FIB-4 and the interrogation

Participating in This Clinical Trial

Inclusion Criteria

  • Age >18 years old – Social insurance – Current hospitalization in any psychiatric unit of the participating center – Adult or legal representative who has given written and informed consent to participate in the study. By default, the oral consent of the adult will be obtained (as well as the written consent of the legal representative) – Information given to the curator(for people under curatorship) Exclusion Criteria:

  • – Clinical state of the patient which do not allow the collection of study data (according to the investigator)

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Hôpital le Vinatier
  • Collaborator
    • Hospices Civils de Lyon
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Benjamin ROLLAND, MD, PhD, Principal Investigator, CH LE VINATIER

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