Magnetic Resonance Imaging in Cerebral Small Vessel Disease

Overview

Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 31, 2025

Detailed Description

Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.

Interventions

  • Diagnostic Test: Magnetic resonance imaging
    • Patients recruited will receive Magnetic resonance imaging.

Arms, Groups and Cohorts

  • Cerebral small vessel disease group
    • Patients with clinically and radiologically evidenced cerebral small vessel disease. Patients are grouped by severity of cerebral small vessel disease assessed by comprehensive MRI findings.

Clinical Trial Outcome Measures

Primary Measures

  • Progression in total cerebral small vessel disease burden
    • Time Frame: 1 year
    • Total cSVD burden assessed by MRI

Secondary Measures

  • Progression in congnitive impairments
    • Time Frame: 1 years
    • Global Z-score by cognitive domain
  • Recurrent ischemic events
    • Time Frame: 1 year
    • Recurrent ischemic stroke, TIA and vascular death
  • Modified Rankin Scale
    • Time Frame: 90 days and 1 year after qualifying event
    • Disability assessed by modified Rankin Scale (mRS). The scores, ranging from 0 (no symptoms) to 6 (death), were recorded by phone call or outpatient consultation. A favorable outcome was defined as mRS score 0-2, unfavorable outcome was defined as mRS score > 2.

Participating in This Clinical Trial

Inclusion Criteria

  • Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarcts and white matter hyperintensity – No disability (modified Rankin's scale < 2) – No dementia (MMSE > 24 and absence of dependence in daily activities) – Able and willing to consent Exclusion Criteria:

  • Contraindications to MRI – Standard MRI of bad quality due to movement artefacts – Pregnant – Unable to tolerate MRI

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Chinese PLA General Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Xin Lou, Department of Radiology – Chinese PLA General Hospital
  • Overall Official(s)
    • Xin Lou, MD, PhD, Principal Investigator, Chinese PLA General Hospital
  • Overall Contact(s)
    • Kun Cheng, M.S., +8619921784434, dr_chengkun@163.com

References

Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol. 2019 Jul;18(7):684-696. doi: 10.1016/S1474-4422(19)30079-1. Epub 2019 May 13.

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