Vasopressor Preload Modulation During General Anaesthesia


Is is debated whether administration of pure vasopressor may augment cardiac output (CO) by means of preload modulation. We wish to test this in 20 patients under general anesthesia, with preload dependency induced by head-up-tilt and preload modulation with infusion of phenylephrine. To document any changes in CO the patients will be monitored by Lithium dilution method. Furthermore we will monitor changes in peripheral perfusion index and test the ability of this non-invasive modality to track changes in CO.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 31, 2023

Clinical Trial Outcome Measures

Primary Measures

  • Changes in cardiac output
    • Time Frame: 30 minutes
  • Changes in peripheral perfusion index
    • Time Frame: 30 minutes

Participating in This Clinical Trial

Inclusion Criteria

  • Planned surgery under general anesthesia Exclusion Criteria:

  • atrial fibrillation – refusal to participate

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Jakob Højlund
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Jakob Højlund, Assistant professor, consultant – Hvidovre University Hospital
  • Overall Official(s)
    • Jakob Højlund, MD, Principal Investigator, Hvidovre University Hospital
  • Overall Contact(s)
    • Jakob Højlund, MD, 25708807,

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