Stenotrophomonas maltophilia is a multi-resistant Gram-negative bacillus and is an opportunistic pathogen. Stenotrophomonas maltophilia infections are associated with a significant morbidity and mortality, particularly in immunocompromised patients. The mortality of infections (bacteremia, pneumonia) related to Stenotrophomonas maltophilia is variable and is estimated between 21 and 69%. Stenotrophomonas maltophilia pneumopathies have been mainly described in patients hospitalized in intensive care and benefiting from mechanical ventilation. The existence of immunosuppression seems to be a risk factor for the transition from Stenotrophomonas maltophilia pulmonary colonization to Stenotrophomonas maltophilia pulmonary infection. The reference treatment for Stenotrophomonas maltophilia-associated pneumonia is the combination of trimethoprim and sulfamthoxazole, a molecule that lung transplant patients routinely receive as a preventive treatment for Pneumocysitis jirovecii infection. There is no consensus on the value of routine dual-antibiotic therapy, and it varies from one center to another and from one country to another. The main objective is to compare the clinical-microbiological evolution of lung transplant patients treated for Stenotrophomonas maltophilia pneumopathy according to the prescription of a mono- or bi-antibiotherapy. The secondary objective is to evaluate the resistance rate of Stenotrophomonas maltophilia strains isolated from respiratory samples according to the anti-pneumocystis prophylactic molecule received by the patient.
- Study Type: Observational
- Study Design
- Time Perspective: Retrospective
- Study Primary Completion Date: January 31, 2022
Clinical Trial Outcome Measures
- Clinical-microbiological course of lung transplant patients treated for Stenotrophomonas maltophilia pneumonia
- Time Frame: Day 1
- This outcome corresponds to the comparison of mortality and recurrence rates of Stenotrophomonas maltophilia pneumonia according to the prescription of mono- or dual-antibiotic therapy.
- Resistance rate of Stenotrophomonas maltophilia strains
- Time Frame: Day 1
- This outcome corresponds to the Trimethorpime/sulfamethoxazole resistance rate of Stenotrophomonas maltophilia strains.
Participating in This Clinical Trial
- Patient whose age ≥ 18 years – Patient who has received a lung (mono or bi-pulmonary) or heart-lung transplant – Patient with documented pneumopathy (clinico-radiological definition) (positive respiratory specimen for Stenotrophomonas maltophilia) – French speaking patient Exclusion Criteria:
- Patient under guardianship or curatorship – Patient deprived of liberty – Patient under court protection – Patient objecting to the use of his data for this research
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- Groupe Hospitalier Paris Saint Joseph
- Provider of Information About this Clinical Study
- Overall Official(s)
- Benoit PILMIS, MD, Principal Investigator, Groupe Hospitalier Paris Saint Joseph
- Overall Contact(s)
- Benoit PILMIS, MD, 144127820, firstname.lastname@example.org
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