Effects of Propofol-Induced Anaesthesia on the ST-segment of the ECG

Overview

The purpose of this study is to assess the effect of propofol induced general anaesthesia on the ST-segment of the electrocardiogram. This will be realised by retrospectively analysing the ECG-recordings from adult patients undergoing any treatment at the Catheterisation Laboratory. The ST-segment and other ECG measurements from induction of anaesthesia up to 20 minutes later, will be assessed and compared to the baseline values of the respective segments acquired before injecting propofol. It is essential in this study to exclude any patients burdened with the diagnosis, suspicion or family history of Brugada syndrome.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: April 2022

Interventions

  • Other: Observational study
    • Retrospective data-analysis

Arms, Groups and Cohorts

  • non-Brugada population
    • Adult patients who underwent general anaesthesia (with propofol as induction agent) at the catheterisation laboratory of the UZ Brussel

Clinical Trial Outcome Measures

Primary Measures

  • ST-segment variations after propofol administration.
    • Time Frame: Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol
    • Determine ST-segment variations in mm (either augmentation or suppression) on the ECG in the 20 minute period after administration of propofol in comparison to the baseline ECG

Secondary Measures

  • Additional ECG-segment variations after propofol administration
    • Time Frame: Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol
    • Assess additional ECG-segments measurements in mm and ms from the ECGs recorded. These include Jp- (mm), QRS- (ms), T(p-e)-segments (ms) and the T(p-e)/QT ratio.

Participating in This Clinical Trial

Inclusion Criteria

  • Induction of anaesthesia with propofol – Monitored anaesthesia in the CathLab of the Universitair Ziekenhuis Brussel Exclusion Criteria:

  • Brugada Syndrome or family history of Brugada syndrome – Paediatric population (age <18) – Patients who did not receive propofol during the procedure – Patients who presented with fever (central core temperature >38,0°C)

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Universitair Ziekenhuis Brussel
  • Provider of Information About this Clinical Study
    • Sponsor

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