Effects of Recurrent PE on Women and Offspring

Overview

The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.

Full Title of Study: “The Effects of Recurrent PE on Women and Offspring’s Health”

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: November 2024

Detailed Description

The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.

Interventions

  • Other: blood pressure,BMI, blood sample
    • Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.

Arms, Groups and Cohorts

  • control
    • pregnancy without preeclampsia
  • preeclampsia
    • pregnancy complicated with preeclampsia at the first delivery or at the second delivery
  • recurrent preeclampsia
    • pregnancy complicated with preeclampsia at two deliveries

Clinical Trial Outcome Measures

Primary Measures

  • blood pressure and hypertension of women
    • Time Frame: 1year after the second deliver
    • blood pressure ≥140/90 mmHg
  • blood pressure and hypertension of women
    • Time Frame: 3 years after the second deliver
    • blood pressure ≥140/90 mmHg
  • blood pressure and hypertension of women
    • Time Frame: 5 years after the second deliver
    • blood pressure ≥140/90 mmHg
  • blood pressure and hypertension of offspring
    • Time Frame: 1 year old
    • blood pressure≥140/90 mmHg
  • blood pressure and hypertension of offspring
    • Time Frame: 3 years old
    • blood pressure≥140/90 mmHg
  • blood pressure and hypertension of offspring
    • Time Frame: 5 years old
    • blood pressure≥140/90 mmHg
  • level of glycosylated hemoglobin in blood
    • Time Frame: 1 year after the second deliver
    • women
  • level of glycosylated hemoglobin in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of glycosylated hemoglobin in blood
    • Time Frame: 5 years after the second deliver
    • women
  • level of cholesterol, LDL, HDL, VLDL-C in blood
    • Time Frame: 1 year after the second deliver
    • women
  • level of cholesterol, LDL, HDL, VLDL-C in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of cholesterol, LDL, HDL, VLDL-C in blood
    • Time Frame: 5 years after the second deliver
    • women
  • level of FT3,FT4, and hTSH in blood
    • Time Frame: 1year after the second deliver
    • women
  • level of FT3,FT4, and hTSH in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of FT3,FT4, and hTSH in blood
    • Time Frame: 5 years after the second deliver
    • women
  • level of AST and ALT in blood
    • Time Frame: 1year after the second deliver
    • women
  • level of AST and ALT in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of AST and ALT in blood
    • Time Frame: 5 years after the second deliver
    • women

Secondary Measures

  • BMI of offspring
    • Time Frame: 1 year old
    • weight(kg)/height(m)2
  • BMI of offspring
    • Time Frame: 3 years old
    • weight(kg)/height(m)2
  • BMI of offspring
    • Time Frame: 5 years old
    • weight(kg)/height(m)2
  • level of insulin in blood
    • Time Frame: 1year after the second deliver
    • women
  • level of insulin in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of insulin in blood
    • Time Frame: 5 years after the second deliver
    • women
  • level of fructosamine in blood
    • Time Frame: 1year after the second deliver
    • women
  • level of fructosamine in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of fructosamine in blood
    • Time Frame: 5 years after the second deliver
    • women
  • level of AI37℃、AI4℃、PRA、ALD、AngII in blood
    • Time Frame: 1 year after the second deliver
    • women
  • level of AI37℃、AI4℃、PRA、ALD、AngII in blood
    • Time Frame: 3 years after the second deliver
    • women
  • level of AI37℃、AI4℃、PRA、ALD、AngII in blood
    • Time Frame: 5 years after the second deliver
    • women

Participating in This Clinical Trial

Inclusion Criteria

  • women with at least twice of delivery history Exclusion Criteria:

  • women with chronic hypertension

Gender Eligibility: Female

Minimum Age: 19 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Dunjin Chen
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Dunjin Chen, Director – Guangzhou Medical University
  • Overall Contact(s)
    • Dunjin Chen, 18928916722, gzdrchen@gzhmu.edu.cn

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