Electrolytes in Chronic Kidney Disease Patients With Acute Coronary Syndrome

Overview

Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.

Full Title of Study: “Study of Serum Calcium and Phosphorus Level in Chronic Kidney Disease Patients With Acute Coronary Syndrome”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: May 30, 2022

Detailed Description

Prospective study to : 1. find the relation between electrolytes disturbance and renal diseases 2. the effect of electrolyte abnormalities on atherosclerosis 3. prevalence of acute coronary syndrome in patients with chronic kidney disease

Interventions

  • Diagnostic Test: Serum Calcium
    • Serum calcium level. Serum phosphorus level. will be measured to all study population

Arms, Groups and Cohorts

  • Chronic Kidney Disease (CKD) patients with acute coronary syndrome
    • The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : Electrocardiogram (ECG) changes: ST elevation. ST depression. T wave inversion. recent left bundle branch block. Troponin elevation.
  • Chronic Kidney Disease (CKD) patients without acute coronary syndrome
    • The CKD patient with or without dialysis with no previous history of ACS.

Clinical Trial Outcome Measures

Primary Measures

  • Chronic kidney disease hospitalization
    • Time Frame: from the day of admission to the day of discharge through study completion, an average of 28 weeks, in sohag university hospital
    • The CKD patient with and without acute coronary syndrome and estimated hazard ratios (HR) by use of multivariable Cox regression models.

Participating in This Clinical Trial

Inclusion Criteria

  • 1-The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : a- Electrocardiogram (ECG) changes: – ST elevation. – ST depression. – T wave inversion. – recent left bundle branch block. b- Troponin T elevation. 2-The CKD patient with or without dialysis with no previous history of ACS. Exclusion Criteria:

1. Patients who were diagnosed with primary hyperparathyroidism. 2. Acute Kidney injury (AKI) which is defined as any of the following:(KDIGO2012)

  • Increase in S.Cr by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) within 48hours; or – Increase in S.Cr to ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days;or – Urine volume <0.5 ml/kg/h for 6 hours

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Sohag University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ahmed Mohamed Youssif, Principal Investigator – Sohag University
  • Overall Contact(s)
    • Ahmed M YOUSEF, M.B.B.CH, 01067439846, ahmed011032@med.sohag.edu.eg

References

Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis. 1998 Apr;31(4):607-17.

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