Assessment of Ultrasonographic Measurement of Inferior Vena Cava Collapsibility Index in Prediction of Hypertension Associated With Tourniquet Release in Total Knee Replacement Surgeries Under Spinal Anesthesia


Administration of intravascular fluids is one of the methods to prevent SA-induced hypotension, but empirical intraoperative volume repletion carries the risk of fluid overload during elective surgery. Over fluid resuscitation is associated with organ dysfunction and higher mortality rate , thus, to avoid ineffective or even harmful intravascular volume expansion, it is important to have tools to predict hypotension and fluid responsiveness.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: November 1, 2021


  • Diagnostic Test: ultrasound
    • Ultrasonographic measurement of Inferior Vena Cava Collapsibility Index

Clinical Trial Outcome Measures

Primary Measures

  • mean arterial blood pressure
    • Time Frame: 15 minutes after tourniquet release

Participating in This Clinical Trial

Inclusion Criteria

  • ASA grade I, II, III – Age 18 -65 yrs – Spinal Anesthesia Exclusion Criteria:

  • Patient refusal – Patient having contraindication of Spinal Anesthesia (infection at the site of injection, spine deformity, coagulation disorders ) . – Known cardiac, renal, neurological, metabolic, endocrine, psychiatric, respiratory disease.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Ain Shams University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Mona Ammar, Assistant Professor – Ain Shams University
  • Overall Contact(s)
    • Mona Ammar, 01006236620,

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