Biomarkers, TCM Body Constitution, Dietary Pattern and Psychological Factors in Predicting Depression Among University Students

Overview

This study aims to determine the predictors of depression among university students in Universiti Tunku Abdul Rahman (UTAR) Sungai Long Campus.

Full Title of Study: “Biomarkers, Traditional Chinese Medicine Body Constitution, Dietary Pattern and Psychological Factors in Predicting Depression Among University Students in UTAR, Malaysia”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: August 2022

Detailed Description

University students are a high at risk group for development of depression. Identifying the determinants of depression could help in the diagnosis and treatment of this disorder. This study will incorporate questionnaire and blood sample data collection procedures on 397 subjects. Written consent will be obtained from the subjects. Eligible subjects will be given self-administered questionnaires which include Patient health questionnaire (PHQ-9), Constitution in Chinese medicine questionnaire (CCMQ), Dysfunctional Attitude Scale (DAS), Depression Anxiety Stress Scales (DASS-21) – stress and anxiety subscales, Perceived stress scale-10 (PSS-10), Rosenberg self-esteem scale (RSES), and Food frequency questionnaire (FFQ). Once the subjects completed the questionnaires, blood samples will be collected from them by a trained phlebotomist. In addition, 10 most high at risk of depression subjects (with PHQ-9 scores 10 and above) and 10 healthy subjects (with PHQ-9 scores lower than 10) will be selected randomly for protein expression to further identify the proteins that significantly expressed among them.

Arms, Groups and Cohorts

  • University students
    • University students in Universiti Tunku Abdul Rahman Sungai Long Campus

Clinical Trial Outcome Measures

Primary Measures

  • Genetic, TCM body constitution, psychological factors and dietary pattern are significant predictors for depression among university students.
    • Time Frame: Baseline
    • Univariate and multivariate logistic regression will be performed.

Secondary Measures

  • Prevalence of depression among university students.
    • Time Frame: Baseline
    • Patient Health Questionnaire (PHQ-9): Non depressed = 0 – 9; Depressed = 10 – 27
  • Protein significantly expressed between depressed and non-depressed students.
    • Time Frame: Baseline
    • Liquid chromatography-mass spectrometry (LC-MS) will be performed.

Participating in This Clinical Trial

Inclusion Criteria

  • Malaysian citizen – Able to read and communicate in English Exclusion Criteria:

  • Special education disability (deaf and blind) – Physical support – History of infectious diseases

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 30 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Universiti Tunku Abdul Rahman
  • Provider of Information About this Clinical Study
    • Principal Investigator: Foo Chai Nien, Assistant Professor – Universiti Tunku Abdul Rahman
  • Overall Official(s)
    • Chai Nien Foo, Principal Investigator, Universiti Tunku Abdul Rahman
  • Overall Contact(s)
    • Chai Nien Foo, +60123167252, foocn@utar.edu.my

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