Investigation of the Relationship Between Salivary Histatine-5 Level and Vaginal Candidiasis in Women


The low Histatine-5 (HST-5) level of the saliva can lead to vaginal candidiasis. Because HST-5 level in the saliva can effect vaginal Ph, flora and local defence mechanisms. Histatine-5 is secreted in the parotis and submandibular glands. İt riches histidine amino ascid and have antifungal activity. Salivary proteins and their plasma levels were found as similar in the literature.

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 2021

Detailed Description

Women with regularly menstrual cycle will enroll in the study than will separate two groups: Study group: women with vaginal candidiasis ( diagnosed by clinic and lab.) Control group: women ( not have any vaginal infections candida and others) Saliva samples will be taken from two groups than HST-5 level will be analyzed. Finally HST-5 levels of the two groups will be compared . Women with diabetes, immun deficiency, pregnancy, virgin, menopausal period , premature ovarian failure will be excluded.


  • Other: salivary sample
    • salivary sample

Arms, Groups and Cohorts

  • Case group
  • Control group

Clinical Trial Outcome Measures

Primary Measures

    • Time Frame: 1 month

Participating in This Clinical Trial

Inclusion Criteria

women with regularly menstrual cycle , diagnosed candidal vaginosis and not have any vaginal infection. - Exclusion Criteria:

diabetes, immun deficiency, menopause, premature ovarian failure, pregnancy, virgin -

Gender Eligibility: Female


Minimum Age: 18 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Usak State Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Irem Senyuva, M.D, Obstetrics and Gynecology – Usak State Hospital


Khurshid Z, Najeeb S, Mali M, Moin SF, Raza SQ, Zohaib S, Sefat F, Zafar MS. Histatin peptides: Pharmacological functions and their applications in dentistry. Saudi Pharm J. 2017 Jan;25(1):25-31. doi: 10.1016/j.jsps.2016.04.027. Epub 2016 May 4. Review.

Loo JA, Yan W, Ramachandran P, Wong DT. Comparative human salivary and plasma proteomes. J Dent Res. 2010 Oct;89(10):1016-23. doi: 10.1177/0022034510380414. Epub 2010 Aug 25. Review.

Liao H, Liu S, Wang H, Su H, Liu Z. Efficacy of Histatin5 in a murine model of vulvovaginal candidiasis caused by Candida albicans. Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx072.

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