Genome-wide Association Study of Development of Collateral Circulation for Patients With Coronary or Peripheral Artery Disease

Overview

The purpose of this study is to evaluate the genome-wide association for the development of collateral circulation for patients with coronary or peripheral artery disease and to develop the molecular genetic treatment model based on genome-wide association data.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 30, 2025

Interventions

  • Diagnostic Test: Blood samples
    • for evaluation of the genome-wide association study

Arms, Groups and Cohorts

  • Coronary Artery Disease_collateral flow grade 2
  • Coronary Artery Disease_collateral flow grade 0
  • Peripheral Artery Disease_collateral flow grade 2
  • Peripheral Artery Disease_collateral flow grade 0

Clinical Trial Outcome Measures

Primary Measures

  • Correlation between genome and collateral flow
    • Time Frame: 5 years

Participating in This Clinical Trial

Inclusion Criteria

  • Age more than 20 – Chronic total occlusive lesion from the coronary or peripheral angiogram Exclusion Criteria:

  • Renal dysfunction – Hepatic dysfunction – Thrombocythemia or thrombocythemia – Planned major surgery in 1 year – History of gastrointestinal haemorrhage – Malignant tumor

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Jung-min Ahn
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Jung-min Ahn, Assistant Professor – Asan Medical Center
  • Overall Contact(s)
    • Jung-hee Ham, Project manager, 82230104728, cvcrc5@amc.seoul.kr

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