ICU Norepinephrine Load


Norepinephrine is recommended as first-line vasopressor in critically ill patients, regardless of shock etiology. Its advantages over dopamine and/or epinephrine have been demonstrated, especially by reducing tachycardia events. The current guidelines recommend a mean arterial pressure of at least 65 mmHg that in the resuscitation from sepsis-induced hypoperfusion. Some study reported that delay in initiation of vasopressor therapy was associated with an increase mortality risk in patient with septic shock .The recent experts' opinion suggest that " vasopressors should be started early, before (complete) completion of fluid ressuscitation ". In the event of refractory septic shock, high-dose vasopressors may be used. The precise maximal dose of norepinephrine associated with mortality excess has been poorly studied. High doses have been defined by a cutoff value ranging from 0.5 μg/kg/min to 2 μg/kg/min and recently by 1 μg/kg/min for mortality at 90% and by 0,75 μg/kg/min for mortality at 60%. Furthermore, an increasing vasopressor dosing intensity during the first 24 hours after shock septic was associated with increased mortality depending of fluid administration. If a threshold value of norepinephrine score can be obtained, it could indicate the association with another vasopressor such as vasopressin or surrogates. The primary aim of the present study aimed to confirm if a given norepinephrine dose is associated with mortality. The secondary aims were the link between mortality and norepinephrine duration, cumulative dose in order to build a score that predicts a futility of increasing norepinephrine dose.

Full Title of Study: “Norepinephrine Load and Relationship With Prognosis in Critically Patients With Circulatory Shock”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: December 2022


  • Drug: Circulatory shock with norepinephrine in ICU
    • Circulatory shock with norepinephrine in ICU

Arms, Groups and Cohorts

  • Group 1: surviving Patients
    • Patients surviving within 5 days of the date of ICU admission for circulatory shock and receiving norepinephrine
  • Group 2: Deceased patients
    • Patients deceased within 5 days of the date of ICU admission for circulatory shock and receiving norepinephrine

Clinical Trial Outcome Measures

Primary Measures

  • Mortality
    • Time Frame: Day 5
    • Mortality within 5 days of the date of ICU admission for circulatory shock according to norepinephrine intensity

Secondary Measures

  • Intensity
    • Time Frame: Day 5
    • Intensity mortality relationship according to norepinephrine duration
  • Time/Dose Ratio
    • Time Frame: Day 5
    • ratio between time of use and cumulative dose
  • Norepinephrine dose
    • Time Frame: Day 5
    • score of increasing norepinephrine dose

Participating in This Clinical Trial

Inclusion Criteria

  • Age > 18 years – circulatory shock and admitted in ICU – with norepinephrine Exclusion Criteria : Patient without norepinephrine or missing data.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Centre Hospitalier Universitaire de Nīmes
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Laurent Muller, MD, PhD, Principal Investigator, Centre Hospitalier Universitaire de Nîmes
  • Overall Contact(s)
    • Laurent Muller, MD, PhD, +33.(0),

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.