Taste Supra-thresholds Among a Sample of Depressed Egyptian Adult Under Anti-depressants Therapy

Overview

Determine the taste intensity at supra-threshold among a sample of depressed Egyptian adults (age from 20 to 50 years old) under anti-depressants therapy ( for at least 3 months) using filter paper disc(FPD) method using a psychophysical method through a scoring system.

Full Title of Study: “Taste Supra-thresholds Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy A Retrospective Cohort Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: April 8, 2021

Detailed Description

PECO – P Population: depressed Egyptian adults under anti-depressants therapy – E1 Exposure 1: Tricyclic antidepressants (Imipramine, Amitriptyline, Clomipramine HCL) – E2 Exposure 2: Selective Serotonin Re-uptake inhibitors antidepressants ( Fluoxetine, Fluvoxamine, Sertraline, Citalopram, Paroxetine) – C control (non exposure) : non-pharmacological treatment ( psychotherapy) – O Outcome: Determine the taste intensity at supra-threshold among these patients using a psychophysical method through a scoring system

Arms, Groups and Cohorts

  • Exposure 1
    • commonly prescribed tricyclic antidepressants (Imipramine, Amitriptyline, Clomipramine HCL) administered for at least 3 months
  • Exposure 2
    • commonly prescribed Selective Serotonin Re-uptake inhibitors antidepressants ( Fluoxetine, Fluvoxamine, Sertraline, Citalopram, Paroxetine) administered for at least 3 months
  • Non exposure
    • Non-pharmacological treatment (psychotherapy)

Clinical Trial Outcome Measures

Primary Measures

  • Taste intensity at supra-threshold
    • Time Frame: during a period of 3 months from February 2021 till April 2021]
    • – C.M will assess the taste intensity at supra-threshold level on a 9 point vertical labeled scale (extremely strong, very strong, strong, slightly strong, neutral, slightly weak, weak , very weak, extremely weak) in which subjects indicate the intensity perceived when tasting a substance

Participating in This Clinical Trial

Inclusion Criteria

  • Depressed Egyptian adults under antidepressants therapy for at least 3 months/non-pharmacological treatment( psychotherapy) • Age from 20 to 50 years old Exclusion Criteria:

  • Antipsychotics – Hypnotics – Anticonvulsants – Ages other than the mentioned • Olfactory dysfunction – Chemosensory dysfunction

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Cairo University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Christine Raouf George Mikhail, Principal Investigator – Cairo University

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