Hyaluronic Acid, Corticosteroid and Electrotherapy in Subacromial Impingement Syndrome


Background: Electrotherapy, corticosteroid, and hyaluronic acid have been used to treat subacromial impingement syndrome. However, we need to compare treatment options to provide the optimal results. This study aims to compare the effect of hyaluronic acid, corticosteroid, and electrotherapy in subacromial impingement syndrome. Design: Ninety five patients were randomised into three equal groups according to treatment types. Hyaluronic acid (20 mg/2ml, three times one week apart) or corticosteroid (triamcinolone acetonide, 40 mg/ml, single dose) treatments were applied as subacromial injections. Electrotherapy consisted of 14 sessions TENS (20 min.), hotpack (20 min.) and ultrasound (1.5watt/cm2, 1 MHz, 6 min.). Patients were evaluated before treatment, one and four weeks post end of treatment. Visual Analogue Scale (VAS), range of motion (ROM), and Shoulder Disability Questionnaire (SDQ) were used as outcome measures.

Full Title of Study: “Subakromiyal sıkışma Sendromunda Hyaluronik Asit, Kortikosteroid ve Elektroterapi”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Single (Outcomes Assessor)
  • Study Primary Completion Date: December 10, 2013


  • Drug: Hyaluronic acid
  • Drug: Corticosteroids Triamcinolone Acetonide
    • triamcinolone acetonide, 40 mg/ml, single dose
  • Other: Electrotherapy
    • electrotherapy

Arms, Groups and Cohorts

  • Active Comparator: Electrotherapy
  • Active Comparator: corticosteroid
  • Active Comparator: hyaluronic acid

Clinical Trial Outcome Measures

Primary Measures

  • Visual Analogue Scale
    • Time Frame: 1 min.
    • Higher scores represent higher level of shoulder pain.
  • range of motion
    • Time Frame: 5 min.
    • Higher scores represent lower level of shoulder function.
  • Shoulder Disability Questionnaire
    • Time Frame: 15 min
    • Higher scores represent higher level of shoulder pain.

Participating in This Clinical Trial

Inclusion Criteria

  • The diagnosis of subacromial impingement syndrome Exclusion Criteria:

  • Patients aged <20 or >50 years or who have the following medical conditions were excluded: physical therapy or injection in the past 6 months, shoulder instability, acute trauma, adhesive capsulitis, psychiatric illness, diabetes mellitus, malignancy.

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Şeyhmus KAPLAN
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Şeyhmus KAPLAN, Department of Sports Medicine – Yuzuncu Yıl University

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