Abbott Vital® as an Alternative Meal to the Gold-standard Egg-white Sandwich for Gastric Emptying Scintigraphy (GES)


This crossover study is designed to compare the rates of gastric emptying between two diagnostic radioactive meals using the gold-standard egg-white sandwich meal and Abbott Vital®. Healthy participants will be recruited and randomly assigned into either groups of Abbott Vital® and gold-standard egg-white sandwich group. The measurements will be performed over a 4-hour period using a gamma camera, and estimated gastric emptying rates will be calculated using established algorithms.

Full Title of Study: “Abbott Vital® as an Alternative Meal to the Gold-standard Egg-white Sandwich for Gastric Emptying Scintigraphy (GES) Among Healthy Volunteers”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 18, 2021

Detailed Description

The gold-standard egg-white sandwich is quite difficult and complicated for staffs to prepare because the food needs to be cooked first and it will take time to prepare. Besides, the egg-white sandwich is not suitable for those with allergies to egg and bread and also to vegetarian patients. This gold-standard meal is also not a common meal for Asian people so some of the people may not tolerate with the meal. The aim of this study is to determine whether Abbott Vital® is as reliable as the gold-standard egg-white sandwich by comparing the gastric meal retention of both meals.


  • Radiation: Egg-white sandwich
    • 1 mCi of Tc-99m sodium phytate is added into the egg-white sandwich
  • Radiation: Abbott Vital®
    • 1 mCi of Tc-99m sodium phytate is added into the Abbott Vital®

Arms, Groups and Cohorts

  • Group 1
    • Egg-white sandwich is added with 1 mCi Tc-99m sodium phytate, then Abbott Vital® added with 1 mCi Tc-99m sodium phytate
  • Group 2
    • Abbott Vital® is added with 1 mCi Tc-99m sodium phytate, then egg-white sandwich added with 1 mCi Tc-99m sodium phytate

Clinical Trial Outcome Measures

Primary Measures

  • Change of gastric emptying rates
    • Time Frame: 4 hours (0 hour, 1/2-hour, 1-hour, 2-hour, 3-hour, 4-hour)
    • Percentage of gastric meal retention (GMR; %)

Secondary Measures

  • Half-emptying time and slope
    • Time Frame: T1/2
    • Time required by the stomach to empty 50% of the ingested meal (T1/2; minutes)
  • Symptoms and satiety/satiation
    • Time Frame: 4 hours (0 hour, 1/2-hour, 1-hour, 2-hour, 3-hour, 4-hour)
    • Intensity of perceived symptom and satiety/satiation based on Visual Analogue Scale (VAS)

Participating in This Clinical Trial

Inclusion Criteria

  • Normal body mass index (BMI) – Able to give consent – 18 years old above Exclusion Criteria:

  • Vegetarian – Allergy or cannot tolerate with milk, egg, and bread – Participants with past and current history of chronic medical illness – Currently on medication that can affect gastrointestinal function are also excluded

Gender Eligibility: All

15 males and 15 females

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Universiti Sains Malaysia
  • Provider of Information About this Clinical Study
    • Principal Investigator: Izleen Laili Binti Ibrahim, Principal Investigator – Universiti Sains Malaysia
  • Overall Official(s)
    • Izleen Laili B Ibrahim, Principal Investigator, Universiti Sains Malaysia


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