Wide-awake surgery with local anesthesia is a widely described approach to performing numerous minor hand procedures, such as tendon repairs and percutaneous fracture pinning, but is less frequently used for hand fractures treated with open reduction internal fixation (ORIF). This is in part due to the need for a tourniquet to visualize the fracture site, however pain-free tourniquet time with local anesthesia is roughly 20 minutes, which is shorter than the average time for fracture fixation (Gillis). While general anesthesia for hand ORIFs may be avoided with more proximal blocks such as a brachial plexus or bier blocks, these still require presence of an anesthesiologist during the procedure, increasing human resource utilization and costs. Development of an anesthetic technique for hand ORIFs which could be performed by surgeons in a clinic setting that provides sufficiently long pain-free tourniquet times could decreases costs, as well as patient wait times. The investigators hypothesize that the pain patients experience after 20 minutes of tourniquet application with local anesthetic infiltration is not due to direct pressure on the proximal arm, but rather distal digital ischemia pain. Previously, it has been shown that ultrasound-guided regional block of the median, radial, and ulnar nerves in the forearm is effective analgesia for awake hand surgery (Winter). Currently, there are no randomized studies investigating if forearm nerve blocks can prolong pain-free tourniquet time compared to local anesthesia infiltration, by blocking this ischemic pain in the distal arm. The investigators' objective is therefore to determine if forearm nerve blocks prolong pain-free tourniquet time compared to local anesthetic infiltration.
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
- Study Primary Completion Date: September 2021
With increasing caseloads in some healthcare systems, patients requiring hand surgery may wait over two weeks for time in the general operating room schedule. During this time, fractures may heal, leading to a need for more extensive and longer procedures such as osteotomies in addition to reduction and fixation. It also prolongs time away from work, as well as home for rural patients who must relocate while awaiting surgery in major centers. Previously, it has been shown that performing closed hand fracture fixation on awake patients in a clinic or procedure room setting leads to 60-100% increases in daily case volume compared to the main operating room (OR) (Gillis, Steve). Fixation of hand fractures in this setting has also been shown to cost over 2000$ less than in the OR, by reducing staffing requirements, equipment, and anesthesia costs (Steve). Performing hand surgery in awake patients under local anesthesia has been shown by numerous studies to be a safe and effective. Wide-awake hand surgery is generally well-tolerated, has lower post-operative opioid requirements, and is often preferred by patients (Thompson). Furthermore, by preventing the need for general anesthesia, this technique allows hand surgery to be performed in patients who may otherwise not be operative candidates. In Canada, awake surgery under local anesthesia is commonly done for tendon repairs, carpal tunnel release, and percutaneous pinning of fractures without a tourniquet (Gillis, Steve, Peters). While tourniquet use improves visualization of the operative field, when only local anesthesia is used patients can typically tolerate the tourniquet for less than 20 minutes before pain begins. For ORIFs, the use of a tourniquet is ideal for exposure of the fracture site. Current literature suggests that the maximum pain-free tourniquet time is roughly 20 minutes, which is less than the average length of fracture fixation in hand fractures (Gillis). Intravenous regional anesthesia (IVRA), i.e. Bier blocks, are well-established means of providing anesthesia for hand surgeries requiring tourniquet use, and enable tourniquet times from 20 minutes to two hours (Dekoninck, Brown). While these blocks prevent the need for general anesthesia, they still require an anesthetist to perform and monitor the block. More recently, forearm tourniquets with IVRA have been shown to be non-inferior to traditional proximal arm tourniquets, with lower doses of post-operative opioids required (Dekoninck, Farbood). However, compared to local anesthesia, IVRA for procedures were tourniquets are preferred still increases costs, staffing requirements, and resource use as they often take place in the OR. However, local anesthetic infiltration by the treating surgeon may not provide sufficient pain relief for the amount of tourniquet time required to complete an average ORIF of a long bone in the hand. Therefore, although many methods of anesthesia for hand ORIFs exist, include local anesthetic infiltration and proximal nerve blocks, there is not yet one 'gold standard' approach. Ultrasound guided peripheral nerve blocks at the forearm level have previously been shown to be a safe, effective method of providing regional anesthesia for minor hand procedures, that are tolerated well by patients (Winter). The technique can be quickly taught to even junior residents, and does not require any specialized equipment outside of the ultrasound probe (Winter). These blocks take roughly five minutes to perform, and anesthesia is achieved after an additional five minutes, shorter than typical times for blind forearm nerve blocks (Lovely). The investigators hypothesize that the pain patients experience after 20 minutes of tourniquet application with local anesthetic infiltration is not due to direct pressure on the proximal arm, but rather distal digital ischemia pain. Previously, it has been shown that ultrasound-guided regional block of the median, radial, and ulnar nerves in the forearm is effective analgesia for awake hand surgery (Winter). Currently, there are no randomized studies investigating if forearm nerve blocks can prolong pain-free tourniquet time compared to local anesthesia infiltration, by blocking this ischemic pain in the distal arm. The investigators' objective is therefore to determine if forearm nerve blocks prolong pain-free tourniquet time compared to local anesthetic infiltration. All patients over 18 years of age, with single meta-carpal or phalangeal fractures will be considered for inclusion. These patients will be identified through femergency room consults, referrals from outside centers, and attending surgeon clinics at the investigators' institution. Currently, if patients require open-reduction internal fixation (ORIF) for these injuries, they are then assessed for suitability for having their procedure while awake using local anesthesia. Patients who are candidates for awake ORIFs will then be informed of the research study by a resident, physician assistant, or attending physician, and have the opportunity to consent to participation. This will not be done by a resident/physician assistant/attending physician who will be performing or assisting with the procedure. Patients who consent to participation will then be randomized to either the control or intervention group. The study will be open-label as both the patient and resident/surgeon will be aware of the type of block (forearm vs local) performed. The risks and benefits associated with forearm and local anesthesia blocks will be explained to the patient as part of the informed consent, prior to randomization. Patients will be recruited from attending physician clinics, however the staff screening patients for eligibility and conducting informed consent will not be the individual who is either a) performing the surgery, or b) collecting, analyzing, or interpreting the data. Patients will have the remaining length of their clinic appointment to contemplate participation in the study. If patients in either group begin to experience pain during their procedure the tourniquet will be taken down and the time will be recorded. Participants in both groups will receive adequate analgesia, as additional local anesthetic will be administered if patients express pain during the procedure. Total procedure time will also be recorded. The resident/physician performing the procedure will record the site of the fracture, type of fixation used (i.e. lag screw, plate), duration of the entire procedure, type and amount of local anesthetic used, and duration of pain-free tourniquet time. Any additional local anesthetic required during the procedure will be recorded. Any deviations from the expected procedure (i.e. need for osteotomy), or other intraoperative complications will also be recorded. The Research Ethics Board (REB) will be notified of any harms to patients, as a result of the study, occur. Any subsequent recommendations from the REB regarding study termination will be followed. If any patients experience local anesthetic toxicity, sustain nerve or blood vessel damage, or experience other intra-operative complications as a result the study intervention(s), the study will be placed on hold until full review of the data is complete, and terminated if appropriate. Patients who were involved of the study to date will be contacted explaining the reason for termination of the study. After the procedure, the resident involved in the procedure will provide the patient with the survey questions. The individuals conducting the surveys will not otherwise be involved in the study. This will be a two question survey recording the amount of pain felt during the procedure and overall experience with their awake hand ORIF. Both questions will be scored on a Numerical analogue scale (NAS) from 1-10. If the patient is unable to physical write due to splinting of the dominant hand, the resident will record the answers verbalized by the patient. Data from the study will be reviewed on a weekly basis. All complications will be noted. Any major complication (resulting in harm or near-harm to a patient) will prompt review of the study data to date for any further complications, including which group the participant(s) experiencing the complication were assigned to.
- Procedure: Forearm nerve block
- Local anesthesia will be used to perform a forearm block of the median, radial, and ulnar nerves.
- Procedure: Local anesthetic infiltration
- Local anesthesia will be infiltrated at the site of injury
Arms, Groups and Cohorts
- Experimental: Forearm Nerve Block
- Patients will receive a nerve block of the radial, median, and ulnar nerves at the level of the forearm using 1% lidocaine with epinephrine. The lidocaine will be injected subcutaneously, using a total dose of less than 7mg per kilogram.
- Active Comparator: Local Anesthetic Infiltration
- Patients will receive local anesthetic infiltration, using 1% lidocaine with epinephrine, to the fracture site and surrounding tissue. No nerve blocks will be performed. The lidocaine will be injected subcutaneously, using a total dose of less than 7mg per kilogram.
Clinical Trial Outcome Measures
- Pain-free tourniquet time (minutes)
- Time Frame: Pain-free tourniquet time; from the time of tourniquet inflation until the patient experiences tourniquet pain, whichever occurs first
- When upper extremity surgery is performed with local anesthesia and a tourniquet, the tourniquet must be removed after roughly 20 minutes as patients begin to feel tingling and pain in their hand. Pain-free tourniquet time refers to the amount of time the tourniquet is applied before the patient begins to feel an uncomfortable sensation or pain in the arm to which the tourniquet is applied. Once pain occurs the tourniquet is released. This will be measured in minutes.
Participating in This Clinical Trial
- English speaking – 18 years of age or older at time of enrollment – are scheduled to undergo an open-reduction internal fixation (ORIF) of a single metacarpal or phalanx Exclusion Criteria:
- Patients with known allergies or intolerance to local anesthetic agents – Patients with multiple fractures – Patients with known chronic pain disorders or peripheral neuropathies – Pediatric patients (<18 years of age) at the time of enrollment – Patients with a history of opioid (or other pain medication) substance use disorders
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- University of Manitoba
- Provider of Information About this Clinical Study
- Principal Investigator: Christian Petropolis, Assistant professor and Residency Program Director, Department of Surgery – University of Manitoba
- Overall Official(s)
- Christian Petropolis, MD, Principal Investigator, University of Manitoba
- Overall Contact(s)
- Justine Ring, MD, 12045574324, email@example.com
Feehan LM, Sheps SB. Incidence and demographics of hand fractures in British Columbia, Canada: a population-based study. J Hand Surg Am. 2006 Sep;31(7):1068-74.
Gillis JA, Williams JG. Cost analysis of percutaneous fixation of hand fractures in the main operating room versus the ambulatory setting. J Plast Reconstr Aesthet Surg. 2017 Aug;70(8):1044-1050. doi: 10.1016/j.bjps.2017.05.011. Epub 2017 May 20.
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Farbood A, Khademi S, Tajvidi R, Hooshangi M, Salari S, Ghani M, Tahmasebi S, Jamali H. Comparison of Intravenous Regional Anesthesia with Single-Cuff Forearm Tourniquet and Hematoma Block and Traditional Method in Patients with Distal Radius Fractures; A Randomized Clinical Trial. Bull Emerg Trauma. 2020 Apr;8(2):77-82. doi: 10.30476/BEAT.2020.46446.
Winter J, McLeod G, Quaife T, Petropolis C. Surgeon-administered Ultrasound-guided Peripheral Nerve Blocks in Outpatient Procedures of the Upper Extremity. Plast Reconstr Surg Glob Open. 2020 Nov 24;8(11):e3227. doi: 10.1097/GOX.0000000000003227. eCollection 2020 Nov.
Lovely LM, Chishti YZ, Woodland JL, Lalonde DH. How Much Volume of Local Anesthesia and How Long Should You Wait After Injection for an Effective Wrist Median Nerve Block? Hand (N Y). 2018 May;13(3):281-284. doi: 10.1177/1558944717709072. Epub 2017 May 26.
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