Prolactin Hormone in Oral Lichen Planus
Overview
Oral lichen planus (OLP) is one of the most common mucosal diseases with autoimmune etio-pathogenesis with involvement of various cytokines similar to psoriasis.It generally occurs more commonly in females, in a ratio of 3:2. prolactin (PRL),It is a peptide hormone that has a role in autoimmune related diseases like systemic lupus erythematosus and , rheumatoid Artheritis. The role of PrL in OLP pathogenesis was never investigated.the aim of this study is to investigate the expression of PRL receptors in tissue biopsies of OLP patients.
Full Title of Study: “Prolactin Hormone in Oral Lichen Planus Tissue Samples”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Cross-Sectional
- Study Primary Completion Date: August 22, 2020
Arms, Groups and Cohorts
- oral lichen planus group
- patients with chronic bollus erosive lichen planus
Clinical Trial Outcome Measures
Primary Measures
- prolactin receptors expression in oral mucous membrane
- Time Frame: 24 hours
- immuno-histochemistry
Participating in This Clinical Trial
Inclusion Criteria
- patients with oral lichen planus – systemically healthy Exclusion Criteria:
- oral lichenoid lesions
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 60 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- October University for Modern Sciences and Arts
- Collaborator
- Al-Azhar University
- Provider of Information About this Clinical Study
- Principal Investigator: Naglaa Elwakeel, professor – October University for Modern Sciences and Arts
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