Prolactin Hormone in Oral Lichen Planus


Oral lichen planus (OLP) is one of the most common mucosal diseases with autoimmune etio-pathogenesis with involvement of various cytokines similar to psoriasis.It generally occurs more commonly in females, in a ratio of 3:2. prolactin (PRL),It is a peptide hormone that has a role in autoimmune related diseases like systemic lupus erythematosus and , rheumatoid Artheritis. The role of PrL in OLP pathogenesis was never investigated.the aim of this study is to investigate the expression of PRL receptors in tissue biopsies of OLP patients.

Full Title of Study: “Prolactin Hormone in Oral Lichen Planus Tissue Samples”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: August 22, 2020

Arms, Groups and Cohorts

  • oral lichen planus group
    • patients with chronic bollus erosive lichen planus

Clinical Trial Outcome Measures

Primary Measures

  • prolactin receptors expression in oral mucous membrane
    • Time Frame: 24 hours
    • immuno-histochemistry

Participating in This Clinical Trial

Inclusion Criteria

  • patients with oral lichen planus – systemically healthy Exclusion Criteria:

  • oral lichenoid lesions

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • October University for Modern Sciences and Arts
  • Collaborator
    • Al-Azhar University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Naglaa Elwakeel, professor – October University for Modern Sciences and Arts

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.