The Role of Lactate in Viral and Bacterial Infection

Overview

Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.

Full Title of Study: “The Role of Lactate From Viral to Bacterial Infection”

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Prospective
• Study Primary Completion Date: December 31, 2024

Detailed Description

Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.

Interventions

• Other: viral infection
  • a child is infected by virus only
• Other: viral and bacterial infection
  • a child is infected by virus and progress to bacterial infection

Arms, Groups and Cohorts

• viral infection
  • a child is infected by virus only
• viral and bacterial infection
  • a child is infected by virus and progress to bacterial infection

Clinical Trial Outcome Measures

Primary Measures

• level of lactate
  • Time Frame: three days after admission
  • level of lactate in both viral and viral and bacterial infection groups
• the level of lactate dehydrogenase(LDH)
  • Time Frame: three days after admission
  • level of LDH in both viral and viral and bacterial infection groups

Participating in This Clinical Trial

Inclusion Criteria

• child's age is from 0 to 18 years – a child is at least diagnosed with viral infection Exclusion Criteria:

one of the following conditions appeared:

• congenital heart disease or other abnormalities – respiratory failure – hereditary and/or metabolic disease

Gender Eligibility: All

Minimum Age: 1 Minute

Maximum Age: 18 Years

Are Healthy Volunteers Accepted: No

Investigator Details

• Lead Sponsor
  • Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
• Collaborator
  • Children’s Hospital of Chongqing Medical University
• Provider of Information About this Clinical Study
  • Principal Investigator: Chen Long,MD, director – Children’s Hospital of Chongqing Medical University
• Overall Contact(s)
  • Chen Long, MD, PhD, +8613883559467, neuroclong@126.com