Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

Overview

Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 1, 2023

Interventions

  • Other: Surgical Site Infection
    • infection at the site of the surgery (spine or abdomen)

Arms, Groups and Cohorts

  • Spine Surgery
    • Pediatric patients presenting for elective spine fusion surgery at Boston Children’s Hospital
  • Abdominal Surgery
    • Pediatric patients presenting for elective abdominal surgery at Boston Children’s Hospital

Clinical Trial Outcome Measures

Primary Measures

  • Neutrophil populations
    • Time Frame: up to 3 days
    • compare neutrophil population between patients with SSI and without SSI by delineating transcriptomic profiles
  • Neutrophil functional impairment
    • Time Frame: up to 3 days
    • illustrate neutrophil subpopulation associated with neutrophil functional impairment and SSIs by probing phagocytosis and reactive oxygen species formation

Participating in This Clinical Trial

Inclusion Criteria

  • scheduled for an elective open gastrointestinal surgical procedure or spine fusion surgery Exclusion Criteria:

  • On chronic immunosuppressive drugs such as chronic corticosteroid use – preexisting immunodeficiency diseases

Gender Eligibility: All

Minimum Age: 12 Months

Maximum Age: 19 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Boston Children’s Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Koichi Yuki, Principal Investigator – Boston Children’s Hospital
  • Overall Official(s)
    • Koichi Yuki, MD, Principal Investigator, Boston Children’s Hospital
  • Overall Contact(s)
    • Koichi Yuki, MD, 617-355-6225, koichi.yuki@childrens.harvard.edu

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.