The Bern Perioperative Biobank

Overview

The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Full Title of Study: “The Bern Perioperative Biobank to Define Perioperative Changes of Molecular Markers of Perioperative Organo-dysfunctions, Inflammation, Adverse Events and Disease Progression”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: December 2026

Arms, Groups and Cohorts

  • All patients
    • Consenting patients undergoing non-emergency surgery with anesthesia

Clinical Trial Outcome Measures

Primary Measures

  • Assessing the change of the metabolic profile in the perioperative setting
    • Time Frame: Before induction of anesthesia as baseline
    • Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients’ clinical outcome.
  • Assessing the change of the metabolic profile in the perioperative setting
    • Time Frame: Ca. 2-5hours later upon finishing the surgery
    • Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients’ clinical outcome.
  • Assessing the change of the metabolic profile in the perioperative setting
    • Time Frame: On postoperative day 1 during the morning round between 07:30-9:00am
    • Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients’ clinical outcome.

Participating in This Clinical Trial

Inclusion Criteria

  • 18 years and older – Written informed consent – Non-emergency surgery Exclusion Criteria – Transient incapacity to consent or insufficient time (< 6h) to consider study participation – No informed consent – Cognitive impairment/Patients unable to consent – Patients who retrospectively expressed their wish to be excluded

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University Hospital Inselspital, Berne
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Frank Stüber, Prof. MD, Study Chair, Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
    • Markus M Lüdi, MD, Study Director, Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
  • Overall Contact(s)
    • Markus M Lüdi, MD, 0316322384, markus.luedi2@insel.ch

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.