The Incidence of Gall Stones After Bariatric Surgery and Its Association With Weight Loss

Overview

The incidence of Gall Stones after Bariatric surgery and its association with weight loss

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Retrospective
• Study Primary Completion Date: December 26, 2019

Detailed Description

Gallstone (GS) formation is common in obese patients, particularly during rapid weight loss.This study aimed to determine the incidence of GS in patients underwent bariatric surgery (BS) and the influence of weight loss on GS formation.

Interventions

• Procedure: bariatric surgery
  • laparoscopic sleeve gastrectomy,or gastric bypass

Clinical Trial Outcome Measures

Primary Measures

• The incidence of Gall Stones after Bariatric surgery
  • Time Frame: the period between December 2018 and December 2019

Secondary Measures

• effect of weight loss on Gall Stones formation after Bariatric surgery
  • Time Frame: the period between December 2018 and December 2019
  • effect of excess weight loss on gall stones formation after bariatric surgery

Participating in This Clinical Trial

Inclusion Criteria

• (BMI) ≥35kg/m2 with one or more obesity-related comorbidities – a BMI > 40 kg/m2 without coexisting medical problems Exclusion Criteria:

-a conrtaindication for bariatric surgery

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Investigator Details

• Lead Sponsor
  • Helwan University
• Provider of Information About this Clinical Study
  • Principal Investigator: Mahmoud alazawy, general surgery assistant lecturer – Helwan University

References

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Neuberg M, Blanchet MC, Gignoux B, Frering V. Long-Term Outcomes After One-Anastomosis Gastric Bypass (OAGB) in Morbidly Obese Patients. Obes Surg. 2020 Apr;30(4):1379-1384. doi: 10.1007/s11695-019-04287-4.

3.Vural A, Goksu K, Kahraman AN et al. Increased gallstone formation after sleeve gastrectomy and the preventive role of ursodeoxycholic acid. Acta Gastroenterol Belg. 2020;83(1):33-38. 4. MAGOULIOTIS D.E., TASIOPOULOU V.S., SVOKOS A.A. et al.Ursodeoxycholic acid in the prevention of gall stone formation after bariatric surgery : A meta-analysis. Obese Sur., 2008, 27 : 3021-3030 5.MANATSATHIT W., LEELASINJAROEN P., AL-HAMID H., et al. The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss. A two-centre retrospective cohort study. Int Jpatients submitted to sleeve gastrectomy compared to normal subjects. Obes Surg., 2009, 19 : 1515-1521. 6. MELISSAS J., KOUKOURAKI S., ASKOXYLAKIS J., et al. Sleeve gastrectomy – Arestrictive procedure? Obes Surg., 2007, 17 : 57-62 7. LI V.K.M., PULIDO N., MARTINEZ-SUARTEZ P.et al. Symptomatic gallstones after sleeve gastrectomy. Surg Endosc., 2009, 23 : 2488-92. 8. Altieri, M. S., Yang, J., Nie, L., Docimo, S et al. Incidence of cholecystectomy after bariatric surgery. Surgery for Obesity and Related Diseases, (2018). 14(7), 992-996. 9. Morais M, Faria G, Preto J, et al. Gallstones and bariatric surgery: to treat or not to treat? World J Surg. 2016;40(12):2904-10. 10.Guzmán HM, Sepúlveda M, Rosso N. et al .Incidence and Risk Factors for Cholelithiasis After Bariatric Surgery [published correction appears in Obes Surg. 2019 May 28;:]. Obes Surg. 2019;29(7):2110-2114. doi:10.1007/s11695-019-03760-4. 11. Sioka E, Zacharoulis D, Zachari E et al. Complicated gallstones after laparoscopic sleeve gastrectomy. J Obes, 2014. 468203.