Association Between Human Immunodeficiency Virus (HIV) Infection and Male Hypogonadism

Overview

Cross-sectional study investigating the prevalence of hypogonadism in HIV-infected MSM population

Study Type

• Study Type: Observational [Patient Registry]
• Study Design
  • Time Perspective: Cross-Sectional
• Study Primary Completion Date: November 2030

Detailed Description

In this study, we conduct a cross-sectional study investigating the prevalence of hypogonadism in HIV-infected MSM population. Age-matched non-HIV infected MSM group will be used as comparison group. We will also determine the risk factors associated with male hypogonadism (age, duration of HIV infection, comorbidities, BMI, ART use). Correlation will be made between serum testosterone levels and sexual function, vitality, exercise capacity, mood, and bone mineral density.

Interventions

• Diagnostic Test: Testosterone
  • Serum total testosterone and free testosterone level

Arms, Groups and Cohorts

• Case group
  • HIV infected men who have sex with men
• Control group
  • HIV non-infected men

Clinical Trial Outcome Measures

Primary Measures

• Symptoms of androgen deficiency
  • Time Frame: 2021-2030
  • We use the score of Androgen Deficiency in Aging Males (ADAM) questionnaire to study the prevalence of hypogonadism in HIV-infected MSM population
• Serum free testosterone
  • Time Frame: 2021-2030
  • We use serum free testosterone to study the prevalence of hypogonadism in HIV-infected MSM population

Participating in This Clinical Trial

Inclusion Criteria

• HIV-infected men who have sex with men – HIV non-infected men Exclusion Criteria:

• Use of testosterone supplement, anabolic steroid in the past one year. – History of pituitary , adrenal or gonad diseases – History of pituitary surgery or radiation therapy – History of systemic chemotherapy – Active opportunistic infection under treatment – Cancer – Severe hepatic, renal or cardiac impairment

Gender Eligibility: Male

Minimum Age: 20 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

• Lead Sponsor
  • National Taiwan University Hospital
• Provider of Information About this Clinical Study
  • Sponsor
• Overall Contact(s)
  • Shyang-Rong Shih, Ph.D., +886-2-2312-3456, srshih@ntu.edu.tw