Sonographic Signs of Gouty Arthritis in a Cohort of Egyptian Patients: a Cross Sectional Multicenter Study

Overview

The study is a cross sectional observational multicenter study. It is established in collaboration with the Egyptian college of rheumatology study group (ECRsg). It is conditioned that all the study participants had either mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal (MTP) joint in patients with a known history of gout or at high risk. Patients with any known chronic arthritis, comprising rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy, will be excluded from the study. None of the participants had a history of intra-articular injection or aspiration in the scanned joints for 3 months prior to the inclusion in the study. The sonographers will be blinded for clinical data and the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. All the sonographers in the study had an experience between 5 and 10 years in the field of musculoskeletal ultrasound.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: March 16, 2021

Interventions

  • Diagnostic Test: Evaluation of sonographic signs of gouty arthritis
    • the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.

Arms, Groups and Cohorts

  • Sohag university recruited patients
  • Minia university recruited patients
  • Assuit university recruited patients
  • Kasr Elini recruited patients
  • Tanta university recruited patients
  • Monofia university recruited patients
  • Aswan university recruited patients
  • Ain shams university recruited patients

Clinical Trial Outcome Measures

Primary Measures

  • Sonographic signs of gouty arthritis in the knee or 1st MTP joint
    • Time Frame: at baseline
    • Erosions, effusion, echogenic foci, and tophus using OMERACT definitions of sonographic signs of gouty arthritis

Participating in This Clinical Trial

Inclusion Criteria

  • mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal – patients with a known history of gout or at high risk Exclusion Criteria:

  • Patients with any known chronic arthritis, comprising rheumatoid arthritis, Sjoegren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy – History of intra-articular injection in the last 3 months.

Gender Eligibility: All

Minimum Age: 40 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Sohag University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ahmed Mahrous, Associate professor – Sohag University
  • Overall Contact(s)
    • Ahmed Elsman, PhD, 01147158755, m2319434@gmail.com

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