Vitamin D deficiency may be under-diagnosed in sickle cell disease French children. Therefore, the investigator need an epidemiologic study about the prevalence of vitamin D deficiency in this specific population. There are not specific guidelines neither testing nor treatment. The investigator propose to test vitamin D status in all children with sickle cell disease who are consulting their referring haematologist doctor or in the emergency ward.
Full Title of Study: “Evaluation of Vitamin D Deficiency Distribution in Children With Sickle Cell Disease Followed in Lyon, France”
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: February 1, 2023
- Biological: 25-OH Vitamin D measure
- As a complement to the off-study prescription, the investigator are taking two 1 mL tubes of extra blood to measure vitamin D, calcium, phosphorus, parathyroid hormone (PTH) and creatinine.
Arms, Groups and Cohorts
- Sickle cell disease children from Lyon, France
- Sickle cell disease children, followed in IHOPe (Institut d’Hématologie et d’Oncologie Pédiatrique) center, consulting their referring haematologist doctor or in emergency ward, with prescribed blood sample.
Clinical Trial Outcome Measures
- Determination of 25-OH Vitamin D level
- Time Frame: Day 1
- We classify vitamin D status as follows : Sufficiency > >75nmol/L (>30 ng/mL) Insufficiency 50-75 nmol/L (20-30 ng/mL) Deficiency 12-50nmol/L (5-20 ng/mL) Severe deficiency <12 nmol/L (<5 ng/mL)
Participating in This Clinical Trial
- Children: under 18 years old – Sickle cell any genetic type homozygous or composite heterozygous – To receive an assessment independently of the study, during a presentation to the emergency ward and/or a follow-up consultation by the hematologist – no parental opposition signed by at least one parent/legal representative and no child opposition – social security beneficiary Exclusion Criteria:
- History of hematologic grafting
Gender Eligibility: All
Minimum Age: N/A
Maximum Age: 17 Years
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- Hospices Civils de Lyon
- Provider of Information About this Clinical Study
- Overall Official(s)
- Valérie LAUNAY, MD, Principal Investigator, Urgences pédiatriques de l’Hôpital Femme Mère Enfant – Hospices Civils de Lyon
- Overall Contact(s)
- Valérie LAUNAY, MD, 04 27 85 62 13, email@example.com
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