The Effects of Different Montages of tDCS on Muscle Strength in Healthy Adults

Overview

To investigate the effects of different montages of tDCS on muscle strength in healthy adults

Full Title of Study: “The Effects of Different Montages of Transcranial Direct Current Stimulation on Muscle Strength in Healthy Adults”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Factorial Assignment
    • Primary Purpose: Treatment
    • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: May 31, 2022

Detailed Description

Electrode montage or placement of tDCS over primary motor cortex can be categorized into unilateral (anodal or cathodal electrode over primary motor area) and bilateral tDCS (both anodal and cathodal electrode over the cortex). Previous studies reported benefits of different tDCS montages on muscle performance in healthy participants. However, there is no guideline for tDCS montages. This study aims to investigate immediate effects of different tDCS montages on muscle strength in healthy participants.

Interventions

  • Device: Transcranial direct current stimulation
    • Dual/Cathodal/Anodal/Sham tDCS will be applied in 2 mA, 20 mins. All experiments will be performed in random order for each subject.

Arms, Groups and Cohorts

  • Experimental: Anodal-tDCS
    • Anodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the supraorbital area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
  • Experimental: Cathodal-tDCS
    • Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) of non-dominant hemisphere and Anode on the supraorbital area of dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
  • Experimental: Dual-tDCS
    • Dual transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the primary motor area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
  • Sham Comparator: Sham-tDCS
    • Dual transcranial direct current stimulation (tDCS) will be applied over C3-C4 or the motor area (M1) for 20 mins. Anode on dominant hemisphere, Cathode on non-dominant hemisphere. The scope of intervention is to investigate effect of tDCS on muscle strength.

Clinical Trial Outcome Measures

Primary Measures

  • Change from baseline muscle strength after tDCS
    • Time Frame: Baseline (Pretest) and 40 minutes ( posttest)
    • Muscle strength will be measured in Newton by using a hand-held dynamometer.

Participating in This Clinical Trial

Inclusion Criteria

1. Healthy adults 2. Age range between 18 – 60 years old 3. Right-handed dominant identified by the Edinburg Handedness Inventory 4. No recent muscle injuries of both limbs for a past 6-months Exclusion Criteria:

1. Consumed caffeine within 24 hours prior the experiment 2. History of neurological symptoms i.e. seizures, weakness, loss of sensation or unclear history of pass illness 3. Present of metal implantation, intracranial shunt, cochlear implantation or cardiac pacemakers 4. Present of opened wound or infectious wound around scalp

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Mahidol University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Wanalee Klomjai, PhD, Study Director, MU

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