Vitamin D Deficiency in Coronary Artery Disease

Overview

Large population cross sectional study, was conducted between 2018-2020 by attendance of 4526 patients in shiraz, Iran. Patients were undergone selective coronary angiography from radial artery approach by an expert interventional cardiologist. 25-hydroxy vitamin D and Hs-CRP levels were measured for all patients

Full Title of Study: “Can Vitamin D Deficiency be a Risk Factor of Coronary Artery Disease?”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: October 12, 2020

Detailed Description

This cross-sectional study was conducted in Shiraz. Clinical data were collected from the patients of Professor Kojuri cardiovascular clinic in Shiraz, Iran ( Iran, Fars Province, Shiraz, Niayesh Boulevard, Email: kojurij@yahoo.com, webpage: http://kojuriclinic.com/ )who came to clinic from March 2018 to March 2020. Inclusion criteria was all of the new patients who referred to Professor Kojuri cardiovascular clinic. Exclusion criteria were patients with more than 100ng/ml 25-hydroxy vitamin D3 serum level, parathyroid disorders, end-stage-renal-disease (ESRD) and paraneoplastic syndromes. Patients with more than 10mg/L Hs-CRP serum level also were excluded. Complete history and physical exam were taken from the patients and risk factors such as hypertension, diabetes mellitus, age and gender were considered. 25-hydroxy vitamin D3 was checked for all patients. Blood pressure and took electrocardiography (ECG) for all patients were done. The dependent variable was the prevalence of Coronary Artery disease; the independent variable was vitamin D deficiency; and intervening factors were age, gender, hypertension, diabetes mellitus and level of Hs-CRP. All Patients were undergone selective coronary angiography from radial artery approach by an expert interventional cardiologist. Angiography videos were reviewed by a team of expert cardiologists. Based on the results of coronary angiography, patients were classified as non-significant CAD with stenosis less than 50% and significant CAD with stenosis more than 50% stenosis. In this review diabetic and hypertensive patients is considered by criteria of American diabetes association 2018 & American heart association 2017 . Patient's serum level of 25-hydroxy vitamin D on their first visit was considered as index of vitamin D level. Vitamin D deficiency and sufficiency are defined respectively as serum level of 25-hydroxy vitamin D less than 30ng/ml and serum level of 25-hydroxy vitamin D more than 30 ng/ml . Patients with Parathyroid disorders and paraneoplastic syndromes were excluded

Interventions

  • Diagnostic Test: coronary angiography
    • extent of coronary artery disease in invasive coronary angiography

Arms, Groups and Cohorts

  • vitamin D deficient
    • those patient with vitamin D level below 30 ng/dl
  • non vitamin D deficient
    • those patient with vitamin D above 30 ng/dl

Clinical Trial Outcome Measures

Primary Measures

  • coronary disease
    • Time Frame: 2 years
    • extent of coronary artery disease in invasive coronary angiography
  • Hs-CRP
    • Time Frame: 2 years
    • level of blood Hs-CRP as marker of inflammation

Participating in This Clinical Trial

Inclusion Criteria

  • patients with suspected coronary artery disease who referred for coronary angiography Exclusion Criteria:

  • patients with Vitamin D more than 100ng/ml – parathyroid disorders – end-stage-renal-disease (ESRD) – paraneoplastic syndromes – Patients with more than 10mg/L Hs-CRP

Gender Eligibility: All

Minimum Age: 51 Years

Maximum Age: 75 Years

Investigator Details

  • Lead Sponsor
    • Shiraz University of Medical Sciences
  • Provider of Information About this Clinical Study
    • Principal Investigator: Javad Kojuri, Professor – Shiraz University of Medical Sciences

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.