VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies

Overview

The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 2023

Interventions

  • Device: IRMf-r (séquence resting state)
    • Functional MRI of functional brain networks

Arms, Groups and Cohorts

  • Patients for whom there is no planned implant surgery
  • Patients for whom implantation surgery is planned

Clinical Trial Outcome Measures

Primary Measures

  • Localization and characterization of neural networks
    • Time Frame: baseline
    • neuronal networks description using rest and morphological functionnal MRIs
  • Evolution of neuronal networks after retinal implantation
    • Time Frame: baseline
    • neuronal networks description using rest and morphological functionnal MRIs

Participating in This Clinical Trial

Inclusion Criteria

  • Patient over 18 years old – Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique – Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months – Express consent to participate in the study – Affiliate or beneficiary of a social security scheme Exclusion Criteria:

  • Patient benefiting from a legal protection measure – Pregnant or breastfeeding woman – Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker). – Other additional ocular pathology that can significantly affect vision – Recent eye surgery less than 3 months old

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Fondation Ophtalmologique Adolphe de Rothschild
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Augustin LECLER, Principal Investigator, Fondation Ophtalmologique A. de Rothschild
  • Overall Contact(s)
    • Amélie YAVCHITZ, 0148036454, ayavchitz@for.paris

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