Effect of Meibomian Gland Related Therapy on the Morphology of Meibomian Gland

Overview

200 participants at Eye Hospital of Wenzhou Medical University during September, 2020 to November, 2020 will be enrolled in this study. The meibomian gland related therapy are pulsed light therapy and meibomian gland hot compress massage.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: January 31, 2021

Interventions

  • Device: Intense pulsed light therapy
    • Patients with xerophthalmia were treated with intense pulsed light of meibomian gland.
  • Other: Hot compress massage
    • Patients with xerophthalmia were treated with hot compress massage of meibomian gland.

Arms, Groups and Cohorts

  • Experimental: Intense pulsed light therapy group
  • Experimental: Hot compress massage group
  • Experimental: Intense pulsed light therapy and hot compress massage group

Clinical Trial Outcome Measures

Primary Measures

  • The length of meibomian glands after the treatment.
    • Time Frame: up to 2 months
    • Length in millimeters.
  • The area of meibomian glands after the treatment.
    • Time Frame: up to 2 months
    • Area in millimeters^2.
  • The percentage of meibomian glands after the treatment.
    • Time Frame: up to 2 months
    • Percentage of meibomian glands in %(area of meibomian glands (mm^2) and area of palpebral conjunctiva (mm^2) will be combined to report percentage of meibomian glands in %) are used to assess this outcome measure.

Participating in This Clinical Trial

Inclusion Criteria

  • Previously untreated patients with xerophthalmia Exclusion Criteria:

  • No history of ocular surgery and trauma – Any eye diseases except xerophthalmia – No treated for xerophthalmia before – Successful completion of follow-ups

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Yune Zhao
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Yune Zhao, Vice president of Eye Hospital of Wenzhou Medical University – Wenzhou Medical University

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