Endocrinological and Neuronal Aspects of Bariatric Surgery

Overview

The overall aim of the proposed project is to investigate the contribution of changes in neuronal food processing, hypothalamic reactivity and hormonal factors to weight loss after bariatric surgery.

Full Title of Study: “Changes in Endocrinological and Central Neuronal Satiety Regulation Following Bariatric Surgery”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2023

Interventions

  • Procedure: bariatric surgery
    • bariatric surgery
  • Dietary Supplement: conservative diet
    • conservative diet

Arms, Groups and Cohorts

  • bariatric surgery participants
    • participants with obesity planning to undergo bariatric surgery
  • conservative diet participants
    • participants with obesity planning to controlled conservative behavioral weight loss program

Clinical Trial Outcome Measures

Primary Measures

  • Change in Functional magnetic resonance imaging following intravenous glucose infusion.
    • Time Frame: 2 weeks before surgery or start of dietary intervention and 2 weeks after surgery or start of dietary intervention.
    • Change in responsivity of the hypothalamus (extracted as percent signal change) as the core region of homeostatic control will be assessed after an intravenous glucose infusion (by calculating the area under the curve of hypothalamic responsivity) before and after bariatric surgery or dietary intervention.
  • Experimental functional magnetic resonance imaging task (gustatory stimulation).
    • Time Frame: 2 weeks before surgery or start of dietary intervention and 2 weeks after surgery or start of dietary intervention.
    • Neuronal gustatory processing of food stimuli will be assessed (ingestion of sweet liquids using a gustometer) using a general linear model (comparing brain activation during ingestion of sweet liquids with brain activation during the ingestion of water) and within as well as between groups analyses. Changes in neural gustatory processing of food stimuli will be assessed before and after bariatric surgery or dietary intervention.
  • Assessment of glucose-induced changes in peripheral ghrelin using blood samples.
    • Time Frame: 15 minutes before and 15 minutes after functional magnetic resonance imaging
    • Blood is collected to measure the concentration of peripheral ghrelin as an indicator of hormonal satiety signaling. Blood samples are collected at the beginning and end of each experimental session to assess the influence of intravenuous infusion of glucose on ghrelin signaling. Blood samples will be analysed using using commercially available kits (enzyme-linked immunosorbent assay).

Participating in This Clinical Trial

Inclusion Criteria

  • planning to undergo bariatric surgery – planning to take part in a conservative diet Exclusion Criteria:

  • inability to undergo fMRI – psychiatric disorders – metabolic disorders

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Investigator Details

  • Lead Sponsor
    • University of Heidelberg Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Joe Simon, Principal Investigator – University of Heidelberg Medical Center
  • Overall Official(s)
    • Adrian Billeter, PD, MD, Principal Investigator, Department of General, Visceral, and Transplantation Surgery, University of Heidelberg
  • Overall Contact(s)
    • Joe J Simon, PD, ++49(0)6221-56-38667, joe.simon@med.uni-heidelberg.de

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