Effect of Antiplatelet Therapy on Cognition After Aneurysmal Subarachnoid Hemorrhage


Deficits in memory, executive function, and language are common cognitive sequelae of aneurysmal subarachnoid hemorrhage (aSAH). Previous study demonstrated that post-treatment antiplatelet therapy reduced risk for delayed cerebral ischemia caused by aSAH. However, the effect of antiplatelet therapy on cognition after aSAH is unclear. The aim of this study was to assess the effect of antiplatelet therapy on cognition after aSAH.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 31, 2021


  • Drug: Antiplatelet Drug
    • aspirin and/or clopidogrel or ticagrelor

Arms, Groups and Cohorts

  • Antiplatelet-N group
    • Patients with ruptured aneurysm underwent coiling alone, without post-treatment antiplatelet therapy
  • Antiplatelet-Y group
    • Patients with ruptured aneurysm underwent stent assisted coiling, with post-treatment antiplatelet therapy (aspirin and/or clopidogrel or ticagrelor)

Clinical Trial Outcome Measures

Primary Measures

  • Montreal Cognitive Assessment (MoCA) Test
    • Time Frame: 6-8 months

Participating in This Clinical Trial

Inclusion Criteria

  • 1. Patients with SAH in whom the aneurysm was proven by conventional angiography; 2. Baseline Hunt-Hess grade I-III; 3. patients received endovascular treatment Exclusion Criteria:

  • 1. Hunt-Hess grade IV-V; 2. Non-aneurysmal SAH; 3. Dementia in other diseases; 4. Lacking of 6-8 month MoCA evaluation.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Investigator Details

  • Lead Sponsor
    • Nanjing Medical University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hai-Bin Shi, Professor – Nanjing Medical University
  • Overall Official(s)
    • Hai Bin Shi, MD, Principal Investigator, The First Affiliated Hospital with Nanjing Medical University
  • Overall Contact(s)
    • Zhen Yu Jia, MD., +86 13770918208, zhenyu_jia@sina.com

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