lncRNA-based Nomogram to Assist Childhood Asthma Diagnosis

Overview

Asthma is the most common chronic disease in children, however, underdiagnosis of childhood asthma is an important issue in asthma management. The lack of reliable and objective diagnostic indicators requires the development of rapid and accurate strategies for the early diagnosis of childhood asthma. Recent studies have found a correlation between long-chain non-coding RNA (lncRNA) expression and childhood asthma, suggesting that lncRNA may be a potential biomarker for asthma diagnosis.

Full Title of Study: “LncRNA and Predictive Model to Improve the Early Diagnosis of Childhood Asthma”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 30, 2022

Detailed Description

The investigators envision exploring the early diagnosis of asthma by combining lncRNA with electronic medical records. In this project, the investigators will combine high-throughput sequencing, asthma case database, electronic medical record and informatics to investigate the feasibility of combining lncRNA with electronic medical record for asthma diagnostic model. The expected results will establish the foundation for the diagnosis and treatment of childhood asthma and open up new ideas.

Arms, Groups and Cohorts

  • It’s just an observational study, no interventions
    • children with recurrent wheezing

Clinical Trial Outcome Measures

Primary Measures

  • rate of early diagnosis of childhood asthma
    • Time Frame: 24 months
    • a diagnosis of transient wheeze or asthma was made by a pediatric pulmonologist. This classification was based on symptoms, use of asthma medication, and lung function features.

Participating in This Clinical Trial

Inclusion Criteria

children with recurrent wheezing Exclusion Criteria:

1. diagnosis of other chronic respiratory disease (e.g. cystic fibrosis, bronchopulmonary dysplasia, etc) 2. immunodeficiency- acquired or congenital 3. neuromuscular disease 4. congenital heart disease

Gender Eligibility: All

Minimum Age: 2 Years

Maximum Age: 5 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Children’s Hospital of Fudan University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Liling Qian, PhD., Study Director, Children’s Hospital of Fudan University
  • Overall Contact(s)
    • Lijuan Liu, MD., +86 021-64931129, lijuanliu16@fudan.edu.cn

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