Association of Oral Lichen Planus and Thyroid Disease

Overview

Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is an association between thyroid disease and oral planus lichen in the population of our patients. In the last few years, a couple of studies have been published in the world literature that have studied the possible association of these diagnoses in different populations. Most of the results showed a higher prevalence of thyroid disease in the population of lichen patients, compared with patients without lichen, although some results are contradictory. Some authors believe that the onset of OLP precedes thyroid dysfunction. In the population of Croatian patients with lichen, no research has been done to study the possible connection between these two diseases. The obtained results could help clarify whether there is a connection between these two diagnoses in the population of our lichen patients and enable earlier detection of patients with thyroid hypofunction.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: April 30, 2020

Interventions

  • Diagnostic Test: determination of thyroid hormones and antibodies
    • TSH, fT3, fT4, anti-TPO and anti-Tg were determined from blood sample

Arms, Groups and Cohorts

  • Oral lichen planus
    • Female patients of the Department of Oral Medicine with oral lichen planus
  • Control
    • Female patients of the Department of Oral Medicine without oral lichen planus or other immune disorders

Clinical Trial Outcome Measures

Primary Measures

  • The prevalence of thyroid diseases in patients with oral lichen planus
    • Time Frame: January 2020-April 2020
    • to determine whether there is a higher prevalence of thyroid disease in patients with oral lichen

Participating in This Clinical Trial

Inclusion Criteria

  • for test group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb with clinically and histopathologically confirmed oral lichen planus – for control group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb, without oral lichen planus or other immune disorders; age matched to test group Exclusion Criteria:

  • male patients; female patients with immune disorders; female patients which are not age-matched to test group

Gender Eligibility: Female

Oral lichen planus and thyroid diseases are more frequent in female gender. We wanted the groups to be as similar in characteristics as possible so we included only females.

Minimum Age: 35 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Zagreb
  • Provider of Information About this Clinical Study
    • Principal Investigator: Božana Lončar Brzak, Assistant Professor – University of Zagreb

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.