Lung Function After Abdominal Surgery

Overview

The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Investigation: The day before surgery and the day after surgery Primary outcome measures: – Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. – PaO2, PaCO2 and oxygen saturation (blood gas)

Full Title of Study: “Hypoxia, Lung Function and Diffusion Capacity After Abdominal Surgery”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 17, 2021

Detailed Description

Postoperative hypoxia complicates 30% – 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%. The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Design: Prospective cohort study Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Method: The day before surgery and the day after surgery: Lung function (Vital capacity and FEV1) using box and diffusion capacity measurements and blood gas measurement Primary outcome measures: – Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. – PaO2, PaCO2 and oxygen saturation (blood gas) Other variables examined: age, sex, height, weight, type of surgery, type of anesthesia, smoking status, length of surgery, previously known lung disease.

Interventions

  • Diagnostic Test: Lung function before and after surgery
    • A diagnostic test

Arms, Groups and Cohorts

  • Abdominal surgery
    • People who to be operated in the abdomen are investigated before and after surgery.

Clinical Trial Outcome Measures

Primary Measures

  • Diffusion capacity for carbon monoxide (DLCO)
    • Time Frame: Change from baseline (the day before surgery) to postoperative day 1 or 2
    • Change in DLCO

Secondary Measures

  • Vital capacity (VC)
    • Time Frame: Change from baseline (the day before surgery) to postoperative day 1 or 2
    • Change in VC
  • Forced expiratory volume (FEV1)
    • Time Frame: Change from baseline (the day before surgery) to postoperative day 1 or 2
    • Change in FEV1
  • Arterial PO2
    • Time Frame: Change from baseline (the day before surgery) to postoperative day 1 or 2
    • Change in arterial PO2
  • Arterial PCO2
    • Time Frame: Change from baseline (the day before surgery) to postoperative day 1 or 2
    • Change in arterial PCO2

Participating in This Clinical Trial

Inclusion Criteria

  • Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital. – Must be able to perform a lung function test Exclusion Criteria:

• Dementia or severe cognitive impairment

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Umeå University
  • Collaborator
    • Karolinska Institutet
  • Provider of Information About this Clinical Study
    • Principal Investigator: Karl A Franklin, Professor – Umeå University
  • Overall Official(s)
    • Karl A Franklin, Prof, Principal Investigator, Inst Surgical and periopertive sciences, Umeå university, Sweden

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